INT133621

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.07
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
retina 2
DRG 2
PFC 2
RGC 2
Faah (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endocannabinoid 27 100.00 Very High Very High Very High
dorsal root ganglion 9 100.00 Very High Very High Very High
alcohol 6 99.00 Very High Very High Very High
Inflammation 10 97.20 Very High Very High Very High
Cannabinoid receptor 3 95.20 Very High Very High Very High
addiction 1 94.68 High High
Cannabinoid 2 93.84 High High
Sciatic nerve 2 89.96 High High
agonist 1 85.20 High High
Peripheral nerve injury 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 100.00 Very High Very High Very High
Injury 2 98.36 Very High Very High Very High
Granulomatous Inflammation 5 97.62 Very High Very High Very High
INFLAMMATION 6 97.20 Very High Very High Very High
Nociception 2 77.68 Quite High
Nervous System Injury 1 75.00 Quite High
Granuloma 1 74.28 Quite High
Cancer 1 73.28 Quite High
Necrosis 1 72.80 Quite High
Pain 1 57.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The original observation that retinal ischemia-reperfusion reduces endogenous AEA via enhanced expression of FAAH supports the deduction that this is implicated in retinal cell loss caused by high IOP in the RGC layer.


Positive_regulation (enhanced) of Gene_expression (expression) of FAAH in RGC
1) Confidence 0.65 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17591864 Disease Relevance 0 Pain Relevance 0
RESULTS: In rat retina, ischemic insult followed by reperfusion resulted in enhanced FAAH activity and protein expression paralleled by a significant decrease in the endogenous AEA tone, whereas the AEA-membrane transporter or the AEA-synthase NAPE-PLD (N-acyl-phosphatidylethanolamine-hydrolyzing-phospholipase-d) were not affected.
Positive_regulation (resulted) of Gene_expression (expression) of FAAH in retina
2) Confidence 0.65 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17591864 Disease Relevance 0 Pain Relevance 0
Granuloma formation was accompanied by a significant decrease in endocannabinoid and palmitoylethanolamide levels paralleled by increased levels of the fatty acid amide hydrolase, responsible for their breakdown.
Positive_regulation (increased) of Gene_expression (levels) of fatty acid amide hydrolase associated with endocannabinoid and granulomatous inflammation
3) Confidence 0.59 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 19931394 Disease Relevance 0.85 Pain Relevance 0.55
An ipsilateral versus contralateral increase in both the size and proportion of FAAH-IR DRG occurred after spinal nerve transection injury but not after chronic inflammation of the rat hindpaw 2 d after injection of complete Freund's adjuvant.
Positive_regulation (increase) of Gene_expression (proportion) of FAAH-IR DRG in DRG associated with dorsal root ganglion, inflammation and injury
4) Confidence 0.50 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19321773 Disease Relevance 1.22 Pain Relevance 0.73
A decreased expression of fatty acid amidohydrolase (FAAH), the main endocannabinoid-degrading enzyme, was found in prefrontal cortex (PFC) of AA rats, and was accompanied by decreased enzyme activity in this region.
Positive_regulation (accompanied) of Gene_expression (expression) of FAAH in PFC associated with endocannabinoid
5) Confidence 0.38 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16482090 Disease Relevance 0 Pain Relevance 0.65

General Comments

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