INT133630

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2011
Negated 6
Speculated 2
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 23.89
Pain Relevance 4.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
pituitary 3
mammary gland 2
MCF-7 2
basal cell 2
MDA-MB-231 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 203 99.98 Very High Very High Very High
agonist 150 99.84 Very High Very High Very High
Snapping jaw 48 99.28 Very High Very High Very High
spinal inflammation 5 97.84 Very High Very High Very High
Pain 98 96.36 Very High Very High Very High
Lasting pain 11 95.12 Very High Very High Very High
Opioid 116 93.96 High High
withdrawal 11 90.48 High High
antagonist 53 90.24 High High
Arthritis 14 83.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 162 99.98 Very High Very High Very High
Cancer 1003 99.76 Very High Very High Very High
Inflammatory Breast Neoplasms 486 99.64 Very High Very High Very High
Breast Cancer 745 99.58 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 134 99.52 Very High Very High Very High
Carcinoma 168 99.28 Very High Very High Very High
Temporomandibular Joint Syndrome 47 99.28 Very High Very High Very High
Disease 254 98.56 Very High Very High Very High
Repression 4 98.20 Very High Very High Very High
Hypersensitivity 10 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The highly specialized and specific mid-secretory repertoire of endometrial gene expression coincides with a reduction in the expression of ER-alpha [10].
Negative_regulation (reduction) of Gene_expression (expression) of ER
1) Confidence 0.52 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0 Pain Relevance 0.05
RESULTS: The lumbosacral pain was significantly alleviated, the time for lumbodorsal morning stiffness was shortened, the levels of BASDAI, BASFI, ESR and CRP were significantly lowered after treatment for 3 months or 6months (P < 0.05), and these improvements were more significant in the treated group as compared with those in the control group (P < 0.05).
Negative_regulation (lowered) of Gene_expression (levels) of ESR
2) Confidence 0.42 Published 2007 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 17633369 Disease Relevance 0.07 Pain Relevance 0
Concomitant with the age related reduction in the oestrogen negative feedback on LH secretion was a decline in hypothalamic oestrogen receptor-alpha (ERalpha) expression and increased expression of repressor of ER activity gene (REA) at 210 days of age.
Negative_regulation (decline) of Gene_expression (expression) of ERalpha
3) Confidence 0.41 Published 2006 Journal Soc Reprod Fertil Suppl Section Abstract Doc Link 16866307 Disease Relevance 0.14 Pain Relevance 0.07
Progesterone receptors (PR) undergo similar changes; we and others previously reported that expression of both ER-alpha and PR are down-regulated at the time of implantation, particularly in the epithelial compartment [3-5].
Negative_regulation (regulated) of Gene_expression (expression) of ER
4) Confidence 0.38 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0 Pain Relevance 0
Progesterone receptors (PR) undergo similar changes; we and others previously reported that expression of both ER-alpha and PR are down-regulated at the time of implantation, particularly in the epithelial compartment [3-5].
Negative_regulation (down) of Gene_expression (expression) of ER
5) Confidence 0.38 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1679803 Disease Relevance 0 Pain Relevance 0
Nonetheless, ER products have reduced pill burden, improved convenience, and patients often prefer the ER formulation over an IR formulation in the setting of chronic pain treatment (Broomhead et al 1997).
Negative_regulation (reduced) of Gene_expression (products) of ER associated with lasting pain
6) Confidence 0.37 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 0.76 Pain Relevance 1.92
Loss of ER expression appears to be the dominant mechanism of de novo resistance, and most ER/progesterone receptor negative (PgR?)
Negative_regulation (Loss) of Gene_expression (expression) of ER
7) Confidence 0.36 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001219 Disease Relevance 0.44 Pain Relevance 0
However, most studies do support that EGFR and ER expression are inversely related, with twice the rate of EGFR positivity among ER- compared to ER+ tumors [23].
Negative_regulation (related) of Gene_expression (expression) of ER associated with cancer
8) Confidence 0.33 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.70 Pain Relevance 0
An "intrinsic gene set" of 476 cDNAs was then used to cluster and segregate the tumours into four major subgroups: 1) a "luminal cell-like" group expressing ER; 2) a "basal cell-like" group expressing cytokeratins 5 and 17, integrin 4, and laminin, but lacking ER expression; 3) a HER2-positive subset; and 4) a "normal" epithelial group.
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of ER in basal cell associated with cancer
9) Confidence 0.32 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 0.89 Pain Relevance 0
In spite of these limitations, there appears to be a relationship between cyclin D1 gene amplification and poor disease outcome in ER-positive patients.144–146 In contrast, cyclin D1 protein expression is associated with a good prognosis in some studies,141,147 potentially as a consequence of its positive relationship with ER expression and negative relationship with RB mutations.
Negative_regulation (relationship) of Gene_expression (expression) of ER associated with disease
10) Confidence 0.30 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.36 Pain Relevance 0
In spite of these limitations, there appears to be a relationship between cyclin D1 gene amplification and poor disease outcome in ER-positive patients.144–146 In contrast, cyclin D1 protein expression is associated with a good prognosis in some studies,141,147 potentially as a consequence of its positive relationship with ER expression and negative relationship with RB mutations.
Negative_regulation (relationship) of Gene_expression (expression) of ER associated with disease
11) Confidence 0.30 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.37 Pain Relevance 0
MDA-MB-231 breast carcinoma cells (ATCC HTB-26) lack ER expression.
Negative_regulation (lack) of Gene_expression (expression) of ER in MDA-MB-231 associated with breast cancer
12) Confidence 0.29 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0.53 Pain Relevance 0.06
In conclusion, vaginal tissue of tumor and control bitches, under different distinct steroid influences, had different ER-alpha expression, whereas ER-alpha expression was not present in neoplastic tissues.
Neg (not) Negative_regulation (present) of Gene_expression (expression) of ER-alpha associated with cancer
13) Confidence 0.28 Published 2006 Journal Theriogenology Section Abstract Doc Link 16483645 Disease Relevance 0.62 Pain Relevance 0.08
In the clinical setting, a quantitative decrease in ER expression was found in over 900 patients with primary breast cancer when HER2 was amplified [5].
Negative_regulation (decrease) of Gene_expression (expression) of ER associated with breast cancer
14) Confidence 0.27 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.48 Pain Relevance 0
In general, the absence of estrogen receptor (ER) and progesterone receptor (PgR) expression has been correlated with a shorter disease-free survival time and overall poor clinical outcome of breast cancer patients, including those with IBC [19].
Negative_regulation (absence) of Gene_expression (expression) of estrogen receptor associated with inflammatory breast neoplasms, breast cancer and disease
15) Confidence 0.27 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.29 Pain Relevance 0.04
In general, the absence of estrogen receptor (ER) and progesterone receptor (PgR) expression has been correlated with a shorter disease-free survival time and overall poor clinical outcome of breast cancer patients, including those with IBC [19].
Negative_regulation (absence) of Gene_expression (expression) of ER associated with inflammatory breast neoplasms, breast cancer and disease
16) Confidence 0.27 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.29 Pain Relevance 0.04
Compared with non-IBC LABC, IBC tumors frequently lacked expression of the cytosolic ER (44% of IBC tumors were ER positive versus 64% of LABC) and PgR (30% of IBC tumors were PgR positive versus 51% of LABC), regardless of menopausal status.
Negative_regulation (lacked) of Neg (lacked) Gene_expression (expression) of ER associated with inflammatory breast neoplasms, endometriosis (extended), cancer and advanced or metastatic breast cancer
17) Confidence 0.23 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 3.14 Pain Relevance 0
Tumour suppression by tamoxifen correlated with decreased expression of the ER-inducible genes presenelin-2 (pS2) and cyclin D1.
Negative_regulation (decreased) of Gene_expression (expression) of ER-inducible associated with cancer
18) Confidence 0.21 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400678 Disease Relevance 1.01 Pain Relevance 0.11
At the higher doses, a statistically significant improvement was seen in the reduction of the ESR (p < 0.05), and a trend towards further improvement in CRP and SAA level reduction.
Negative_regulation (reduction) of Gene_expression (reduction) of ESR
19) Confidence 0.21 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.45 Pain Relevance 0.09
A second method is to reduce or eliminate ER expression.
Negative_regulation (reduce) of Gene_expression (expression) of ER
20) Confidence 0.20 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.43 Pain Relevance 0

General Comments

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