INT133632

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.79
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
U-937 2
arcuate nucleus 2
neurons 2
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 14 97.86 Very High Very High Very High
Osteoarthritis 56 97.00 Very High Very High Very High
Kappa opioid receptor 16 96.24 Very High Very High Very High
Dynorphin 28 95.32 Very High Very High Very High
Pain 46 90.92 High High
Lasting pain 24 88.24 High High
Pain score 2 86.68 High High
Spinal cord 8 79.12 Quite High
opioid receptor 5 77.80 Quite High
Pain management 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Repression 10 100.00 Very High Very High Very High
Frailty 58 97.00 Very High Very High Very High
Parkinson's Disease 23 96.72 Very High Very High Very High
Pain 76 90.92 High High
Hypertrophy 1 86.20 High High
Reprotox - General 1 2 84.36 Quite High
Endometriosis (extended) 3 83.60 Quite High
Generalized Anxiety Disorder 4 79.12 Quite High
Dyskinesias 43 78.64 Quite High
Disease 43 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Investigations in rodents (Gerfen et al., 1990; Engber et al., 1992; Duty et al., 1998), primates (Herrero et al., 1995; Morissette et al., 1999; Tel et al., 2002) and humans (Nisbet et al., 1995; Calon et al., 2002; Henry et al., 2003) have shown that Parkinsonism is associated with an increased expression of the opioid precursor preproenkephalin-A (PPE-A) messenger RNA (mRNA) in striatal neurons projecting to the GPe and a decreased preproenkephalin-B (PPE-B) mRNA expression in striatal neurons projecting to the GPi.
Negative_regulation (decreased) of Transcription (expression) of preproenkephalin-B in neurons associated with parkinson's disease and opioid
1) Confidence 0.57 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.45 Pain Relevance 0.35
Taken together, our results suggested the U-937 cells expressed adult brain-type PDYN mRNA which was down-regulated by activation of the cells with LPS due to an inhibition of PDYN gene transcription.
Negative_regulation (inhibition) of Transcription (transcription) of PDYN gene in U-937
2) Confidence 0.43 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16483672 Disease Relevance 0 Pain Relevance 0.03
Moreover, ovariectomy decreases the expression of prodynorphin gene transcripts in the arcuate nucleus of the ewe.
Negative_regulation (decreases) of Transcription (expression) of prodynorphin in arcuate nucleus
3) Confidence 0.40 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 19094085 Disease Relevance 0.34 Pain Relevance 0.14
Since repression of pdyn transcription persists after inhibiting DREAM translation, DREAM appears to play no functional role in the kappa opioid receptor system in OA SFLCs.
Negative_regulation (repression) of Transcription (transcription) of pdyn associated with repression, kappa opioid receptor and osteoarthritis
4) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483451 Disease Relevance 1.05 Pain Relevance 0.75
However, mRNA expression of pdyn was detectable neither in PBMCs derived from the healthy control group nor in PBMCs from OA patients.


Neg (neither) Negative_regulation (detectable) of Transcription (expression) of pdyn associated with osteoarthritis
5) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483451 Disease Relevance 0.95 Pain Relevance 0.69

General Comments

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