INT133633

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.01
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Darc) signal transducer activity (Darc)
Anatomy Link Frequency
brain 2
blood 1
neutrophil 1
Darc (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 197 100.00 Very High Very High Very High
Arthritis 50 97.16 Very High Very High Very High
Inflammation 73 79.52 Quite High
cytokine 28 66.56 Quite High
Chronic pancreatitis 4 50.00 Quite Low
cINOD 4 50.00 Quite Low
Inflammatory response 12 21.40 Low Low
methotrexate 14 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 97 99.54 Very High Very High Very High
Juvenile Chronic Polyarthritis 40 97.16 Very High Very High Very High
Infection 96 96.00 Very High Very High Very High
American Trypanosomiasis 2 92.64 High High
Disease 28 91.28 High High
Arthritis 10 90.64 High High
Targeted Disruption 4 84.12 Quite High
INFLAMMATION 83 79.52 Quite High
Neutropenia 9 76.08 Quite High
Pancreatitis 4 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Individuals who lack DARC are resistant to P. vivax malaria because the merozoite uses DARC to enter red cells (Miller et al, 1976).
Positive_regulation (uses) of DARC associated with malaria and chemokine
1) Confidence 0.38 Published 2008 Journal British Journal of Haematology Section Body Doc Link PMC2655355 Disease Relevance 0.24 Pain Relevance 0.34
When adjusted for other risk factors, co-prescription of GPD was significantly increased in patients aged 55 years and above (odds ratio (OR): 1.29, 95% confidence interval (CI): 1.01-1.64) with no further increase in the co-prescription in older subjects.
Positive_regulation (increased) of GPD
2) Confidence 0.38 Published 2006 Journal Osteoarthr. Cartil. Section Body Doc Link 16483807 Disease Relevance 0.07 Pain Relevance 0
Sequence and functional analysis indicate that both human and mouse express a number of neutrophil-activating chemokines.
Positive_regulation (activating) of chemokines in neutrophil associated with chemokine
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.23 Pain Relevance 0.13
This increase in expression of these chemokines occurs before brain lesions developed in infected rats, implying that the induction of these chemokines could be directly responsible for the observed rat brain lesions [34].
Positive_regulation (induction) of chemokines in brain associated with chemokine
4) Confidence 0.01 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.41 Pain Relevance 0.22
It has been observed that C-C chemokines, such as MIP-1-alpha and RANTES, are significantly upregulated in brains of Trypanosoma brucei brucei infected rats [34].
Positive_regulation (upregulated) of chemokines in brains associated with chemokine
5) Confidence 0.01 Published 2005 Journal Malar J Section Body Doc Link PMC1343570 Disease Relevance 0.39 Pain Relevance 0.23
All three of these chemokines are highly expressed at the level of mRNA, with the most significant increase in mRNA levels being demonstrated for CCL5 when compared with matched peripheral blood samples and controls.
Positive_regulation (increase) of chemokines in blood associated with chemokine
6) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526593 Disease Relevance 0.60 Pain Relevance 0.52
Further, comparative analysis by semiquantitative RT-PCR analysis was performed for other CXC/CC chemokines (CXCL9, CXCL11, CCL3, CCL4, CCL5) and receptor (CCR5) which revealed their upregulation in the diseased state.
Positive_regulation (upregulation) of chemokines
7) Confidence 0.00 Published 2007 Journal Pancreatology Section Body Doc Link 17912012 Disease Relevance 0.06 Pain Relevance 0

General Comments

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