INT133637

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
brain 2
Dbh (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 5 100.00 Very High Very High Very High
Morphine 5 99.32 Very High Very High Very High
addiction 4 97.80 Very High Very High Very High
cocaine 2 97.44 Very High Very High Very High
Locus ceruleus 1 97.16 Very High Very High Very High
withdrawal 2 95.56 Very High Very High Very High
antagonist 1 86.56 High High
opiate 4 81.20 Quite High
alcohol 1 74.80 Quite High
Disease Link Frequency Relevance Heat
Cocaine Dependence 1 97.44 Very High Very High Very High
Drug Dependence 2 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine-induced locomotion was partially restored by DBH expression in either brain region.
Negative_regulation (restored) of Gene_expression (expression) of DBH in brain associated with morphine
1) Confidence 0.43 Published 2006 Journal Science Section Abstract Doc Link 16484499 Disease Relevance 0 Pain Relevance 0.74
Of particular interest is disulfiram, an inhibitor of the NE biosynthetic enzyme dopamine beta-hydroxylase, which has demonstrated promising efficacy in the treatment of cocaine dependence in preliminary clinical trials.
Negative_regulation (inhibitor) of Gene_expression (biosynthetic) of dopamine beta-hydroxylase associated with addiction, dopamine and cocaine
2) Confidence 0.40 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17164822 Disease Relevance 0.25 Pain Relevance 0.71

General Comments

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