INT133638

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2011
Negated 4
Speculated 1
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.23
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
horn 1
brain 1
dorsal root ganglia 1
locus coeruleus 1
Dbh (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 19 100.00 Very High Very High Very High
Spinal cord 8 99.56 Very High Very High Very High
Dorsal horn 6 99.18 Very High Very High Very High
Morphine 19 99.08 Very High Very High Very High
opiate 10 98.40 Very High Very High Very High
noradrenaline 12 98.28 Very High Very High Very High
Neurotransmitter 4 98.12 Very High Very High Very High
Locus ceruleus 5 97.96 Very High Very High Very High
cocaine 8 97.44 Very High Very High Very High
monoamine 2 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 99.88 Very High Very High Very High
Cocaine Dependence 1 97.44 Very High Very High Very High
Drug Dependence 2 82.16 Quite High
Pain 5 75.00 Quite High
Ganglion Cysts 2 75.00 Quite High
Depression 3 25.00 Low Low
Body Weight 3 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Viral restoration of DBH expression in the nucleus tractus solitarius, but not in the locus coeruleus, restored CPP for morphine.
Gene_expression (expression) of DBH in locus coeruleus associated with locus ceruleus and morphine
1) Confidence 0.78 Published 2006 Journal Science Section Abstract Doc Link 16484499 Disease Relevance 0 Pain Relevance 0.74
Morphine-induced locomotion was partially restored by DBH expression in either brain region.
Gene_expression (expression) of DBH in brain associated with morphine
2) Confidence 0.78 Published 2006 Journal Science Section Abstract Doc Link 16484499 Disease Relevance 0 Pain Relevance 0.74
To determine whether noradrenaline (NA) is an essential neurotransmitter for addictive and appetitive behaviors, we measured drug and food seeking in transgenic mice lacking dopamine beta-hydroxylase (Dbh), the enzyme responsible for synthesizing NA.
Neg (lacking) Gene_expression (lacking) of dopamine beta-hydroxylase associated with targeted disruption, dopamine, neurotransmitter and noradrenaline
3) Confidence 0.68 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16899413 Disease Relevance 0.10 Pain Relevance 0.60
To determine whether noradrenaline (NA) is an essential neurotransmitter for addictive and appetitive behaviors, we measured drug and food seeking in transgenic mice lacking dopamine beta-hydroxylase (Dbh), the enzyme responsible for synthesizing NA.
Neg (lacking) Gene_expression (lacking) of Dbh associated with targeted disruption, dopamine, neurotransmitter and noradrenaline
4) Confidence 0.68 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16899413 Disease Relevance 0.10 Pain Relevance 0.60
In mice lacking dopamine beta-hydroxylase (DBH), an enzyme critical for NE synthesis, we found that NE was necessary for morphine-induced conditioned place preference (CPP; a measure of reward) and locomotion.
Neg (lacking) Gene_expression (lacking) of DBH associated with dopamine and morphine
5) Confidence 0.67 Published 2006 Journal Science Section Abstract Doc Link 16484499 Disease Relevance 0 Pain Relevance 0.70
Of particular interest is disulfiram, an inhibitor of the NE biosynthetic enzyme dopamine beta-hydroxylase, which has demonstrated promising efficacy in the treatment of cocaine dependence in preliminary clinical trials.
Gene_expression (biosynthetic) of dopamine beta-hydroxylase associated with addiction, dopamine and cocaine
6) Confidence 0.64 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17164822 Disease Relevance 0.25 Pain Relevance 0.71
In the dorsal horn of the spinal cord, no differences were detected between GalOE-DBH and WT mice, both displaying a strong galanin-positive neuropil in the superficial laminae of the dorsal horn, but the transgenic mice showed a more abundant galanin-positive innervation of the ventral horn.
Neg (no) Gene_expression (detected) of GalOE-DBH in horn associated with targeted disruption, dorsal horn and spinal cord
7) Confidence 0.58 Published 2006 Journal J. Chem. Neuroanat. Section Abstract Doc Link 16546349 Disease Relevance 0.46 Pain Relevance 0.53
The distribution of galanin was studied in the lumbar 5 dorsal root ganglia (DRGs) and spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing galanin under the dopamine beta-hydroxylase (DBH) promoter (GalOE-DBH mice) and in wild type (WT) mice.
Gene_expression (overexpressing) of DBH in dorsal root ganglia associated with targeted disruption, dopamine and spinal cord
8) Confidence 0.58 Published 2006 Journal J. Chem. Neuroanat. Section Abstract Doc Link 16546349 Disease Relevance 0.31 Pain Relevance 0.34
To explore this possibility, we examined the expression of TH, the essential enzyme for the synthesis of both dopamine and norepinephrine, and Dbh, an enzyme that converts dopamine into norepinephrine [25] in Lmx1b iCKO mice.
Spec (examined) Gene_expression (expression) of Dbh associated with dopamine
9) Confidence 0.53 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016403 Disease Relevance 0 Pain Relevance 0.50

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