INT133641

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.23
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL28) extracellular region (CCL28)
Anatomy Link Frequency
smooth muscle cell 1
CCL28 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 87 100.00 Very High Very High Very High
spastic colon 193 99.76 Very High Very High Very High
chemokine 99 98.48 Very High Very High Very High
antagonist 21 96.04 Very High Very High Very High
Inflammation 13 80.56 Quite High
nud 16 72.80 Quite High
addiction 4 69.32 Quite High
alcohol 4 68.88 Quite High
agonist 7 62.32 Quite High
Pain score 3 55.96 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

192 99.76 Very High Very High Very High
Constipation 13 96.96 Very High Very High Very High
Diarrhoea 3 94.68 High High
INFLAMMATION 16 80.56 Quite High
Dyspepsia 16 72.80 Quite High
Disease 22 70.88 Quite High
Gallstones 4 70.56 Quite High
Panic Disorder 3 70.04 Quite High
Alcohol Addiction 3 69.32 Quite High
Schizophrenia 3 68.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexloxiglumide, the active enantiomer of loxiglumide, interacts competitively with CCK1 receptors as determined in preclinical studies, such as specific radioligand binding assays or functional studies on isolated guinea pig gallbladder, where it inhibited smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8), the most prominent active forms of cholecystokinin.
CCK1 Binding (interacts) of in smooth muscle cell associated with cholecystokinin
1) Confidence 0.47 Published 2003 Journal Minerva Gastroenterol Dietol Section Abstract Doc Link 16484960 Disease Relevance 0 Pain Relevance 0.24
The reduced contraction is caused by a lower cholecystokinin (CCK)-8 binding to CCK-1 receptors (CCK-1R) due to caveolar sequestration of receptors.
CCK-1 Binding (binding) of associated with cholecystokinin
2) Confidence 0.47 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20558763 Disease Relevance 0 Pain Relevance 0.30
In summary, we have shown that CCK1 receptor polymorphisms are associated with IBS.
CCK1 Binding (associated) of associated with spastic colon
3) Confidence 0.34 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879831 Disease Relevance 0.07 Pain Relevance 0.69
CCK1 receptor intron 1 779 T > C and exon 1 G > A polymorphism in the IBS patients and in healthy controls
CCK1 Binding (intron) of associated with spastic colon
4) Confidence 0.34 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879831 Disease Relevance 0.19 Pain Relevance 0.86
However, we did not find any association between the CCK1 receptor intron 1 779 T > C polymorphic type and patients with IBS-D, implying that the genetic variation was only associated with IBS patients of 'non IBS-D' type from our study.
CCK1 Binding (association) of associated with spastic colon
5) Confidence 0.34 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879831 Disease Relevance 0.65 Pain Relevance 1.24
Applied Biosystems Taqman Gene expression assays, and Taqman Universal PCR master mix (Applied Biosystems, Nieuwerkerk a/d IJssel, The Netherlands) were used to perform qRT-PCR on FGFBP1 (Hs00183226_m1, Applied Biosystems), TMEM45A (Hs01046616_m1, Applied Biosystems), FKBP7 (Hs00383941_m1, Applied Biosystems), CCL28 (Hs00955110_m1, Applied Biosystems), and the housekeeping gene GAPDH (Hs02758991_g1, Applied Biosystems), which is among the most constantly expressed mRNAs [18].
CCL28 Binding (perform) of
6) Confidence 0.33 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0 Pain Relevance 0
Human “CC” chemokines (structurally characterized by four cysteines) includes 28 members, called CCL1-28 that bind at least 10 receptors (CCR1-10).
CCL1-28 Binding (bind) of associated with chemokine
7) Confidence 0.01 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.08 Pain Relevance 0.39

General Comments

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