INT133652

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.64
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo, TNF) extracellular region (Epo, TNF) signal transduction (TNF)
aging (Epo) plasma membrane (TNF) intracellular (TNF)
Anatomy Link Frequency
Schwann cells 2
Epo (Rattus norvegicus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 80.04 Quite High
Neuropathic pain 2 76.28 Quite High
Peripheral nerve injury 2 75.00 Quite High
cytokine 2 68.16 Quite High
Inflammation 2 67.76 Quite High
Lasting pain 2 66.08 Quite High
Sciatic nerve 2 61.56 Quite High
Disease Link Frequency Relevance Heat
Injury 14 100.00 Very High Very High Very High
Death 4 88.08 High High
Nervous System Injury 4 82.68 Quite High
Pain 8 80.04 Quite High
Neuropathic Pain 2 76.28 Quite High
Wallerian Degeneration 4 75.00 Quite High
Necrosis 2 69.12 Quite High
Cancer 2 68.76 Quite High
INFLAMMATION 2 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest a model in which rhEpo counteracts the effects of TNF-alpha in CCI by blocking expression of TNF-alpha in Schwann cells.
rhEpo Negative_regulation (blocking) of Gene_expression (expression) of TNF-alpha in Schwann cells associated with injury
1) Confidence 0.35 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16487143 Disease Relevance 1.35 Pain Relevance 0.49
RhEpo inhibited TNF-alpha expression in response to lipopolysaccharide, supporting the conclusions of our in vivo CCI experiments.
RhEpo Negative_regulation (inhibited) of Gene_expression (expression) of TNF-alpha associated with injury
2) Confidence 0.35 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16487143 Disease Relevance 1.29 Pain Relevance 0.47

General Comments

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