INT133674

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.11
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Bace1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 8 99.90 Very High Very High Very High
qutenza 18 99.12 Very High Very High Very High
Morphine 4 99.04 Very High Very High Very High
Abeta 8 98.86 Very High Very High Very High
tetrodotoxin 3 90.16 High High
Inflammation 2 81.08 Quite High
Opioid 1 66.36 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 8 89.20 High High
Disease 3 87.40 High High
INFLAMMATION 2 81.08 Quite High
Cognitive Disorder 1 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The APP mRNA and PKC and BACE protein levels were unchanged after capsaicin treatment.
Gene_expression (levels) of BACE protein associated with kinase c and qutenza
1) Confidence 0.61 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428784 Disease Relevance 0.32 Pain Relevance 0.91
The protein kinase C (PKC) translocation state in the soluble and membrane-bound fractions and the levels of beta-secretase (BACE) were also evaluated.
Gene_expression (levels) of beta-secretase associated with kinase c
2) Confidence 0.61 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428784 Disease Relevance 0.33 Pain Relevance 0.91
Inhibition of cathepsin B (catB) activity with CA074Me or attenuation of catB expression through small interfering RNA produced decreases in Abeta release, similar to levels produced with suppression of beta-site APP-cleaving enzyme 1 (BACE1) expression.
Gene_expression (expression) of beta-site APP-cleaving enzyme 1 associated with abeta
3) Confidence 0.42 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.22 Pain Relevance 0.54
In contrast, in the applied single dosage chronic morphine treatment did not influence either the APP and BACE protein levels or the APP mRNA production.
Gene_expression (production) of BACE protein associated with morphine
4) Confidence 0.29 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.24 Pain Relevance 0.41

General Comments

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