INT13368

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 1984
Last Reported 1996
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.46
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (Hils1) chromosome (Hils1) nucleus (Hils1)
DNA binding (Hils1)
Anatomy Link Frequency
thalamus 1
Hils1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 14 99.32 Very High Very High Very High
Antinociceptive 4 98.56 Very High Very High Very High
qutenza 5 97.16 Very High Very High Very High
Thalamus 2 96.16 Very High Very High Very High
anesthesia 1 94.60 High High
Morphine 4 93.36 High High
agonist 4 92.12 High High
opioid receptor 2 91.76 High High
Pain 1 89.40 High High
lidocaine 1 87.76 High High
Disease Link Frequency Relevance Heat
Shock 4 90.08 High High
Pain 1 89.40 High High
Endotoxemia 1 75.00 Quite High
Arthritis 2 74.08 Quite High
Nociception 1 71.76 Quite High
Heart Rate Under Development 1 48.96 Quite Low
Hypoglycemia 1 46.72 Quite Low
Pressure Volume 2 Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals were pretreated with saline, a combination of the H1 and H2 receptor antagonists diphenhydramine (20 mg/kg) and cimetidine (80 mg/kg), or individual doses of diphenhydramine or cimetidine.
H1 Binding (combination) of associated with antagonist
1) Confidence 0.23 Published 1985 Journal Circ. Shock Section Abstract Doc Link 2414028 Disease Relevance 0.17 Pain Relevance 0.27
On the basis of the present electrophysiological results, we suggest that a specific interaction of histamine with H1 receptors may be important for its antinociceptive effect on afferent peripheral inputs to the thalamus.
H1 Binding (interaction) of in thalamus associated with thalamus and antinociceptive
2) Confidence 0.09 Published 1996 Journal Experientia Section Abstract Doc Link 8575561 Disease Relevance 0.20 Pain Relevance 0.48
The secretion evoked by topically applied histamine was resistant to pretreatment with H1 and H2 receptor antagonists i.p.
H1 Binding (pretreatment) of associated with antagonist
3) Confidence 0.08 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2566487 Disease Relevance 0 Pain Relevance 0.18
This response was blocked by pretreatment with H1 and H2 receptor antagonists, but only slightly reduced after systemic capsaicin pretreatment of guinea-pigs.
H1 Binding (pretreatment) of associated with qutenza and antagonist
4) Confidence 0.03 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6083460 Disease Relevance 0.09 Pain Relevance 0.67
The effect of Leu-enkephalinamide was not changed by pretreatment with the histamine H1- and H2-receptor antagonists mepyramine and cimetidine.
H1 Neg (not) Binding (pretreatment) of associated with antagonist
5) Confidence 0.02 Published 1991 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1667847 Disease Relevance 0 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox