INT133681

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 5.38
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc3r) plasma membrane (Mc3r) signal transducer activity (Mc3r)
Anatomy Link Frequency
temporal lobe 6
blood 4
monocyte 2
body 2
frontal cortex 2
Mc3r (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 222 99.90 Very High Very High Very High
chemokine 30 98.88 Very High Very High Very High
antagonist 12 91.88 High High
agonist 24 91.24 High High
Inflammatory response 6 81.68 Quite High
Arthritis 18 76.80 Quite High
Neuropeptide 12 75.00 Quite High
ischemia 6 72.60 Quite High
cytokine 60 71.20 Quite High
Opioid 4 71.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 270 99.90 Very High Very High Very High
Obesity 66 99.84 Very High Very High Very High
Injury 12 99.60 Very High Very High Very High
Urological Neuroanatomy 8 99.48 Very High Very High Very High
Body Weight 30 97.88 Very High Very High Very High
Adhesions 12 93.56 High High
Arthritis 24 92.80 High High
Coronary Artery Disease 6 88.32 High High
Diabetes Mellitus 18 87.24 High High
Stress 12 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exposure of mice to cat odour caused only minor changes in the gene expression of wild-type mice, whereas in homozygous animals a significantly increased expression of the Mc3r gene in the frontal cortex and temporal lobe, and the Pomc1 gene in the temporal lobe, mesencephalon and mesolimbic area was established.
Positive_regulation (increased) of Gene_expression (expression) of Mc3r in temporal lobe associated with urological neuroanatomy
1) Confidence 0.67 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16488027 Disease Relevance 0.28 Pain Relevance 0.11
In summary, it appears that 12 weeks of moderate-intense resistance training led to a 16-fold upregulation of MC3R gene expression in whole blood from obese postmenopausal women.
Positive_regulation (upregulation) of Gene_expression (expression) of MC3R gene in blood associated with obesity
2) Confidence 0.67 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.26 Pain Relevance 0.17
The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7 ± 3.7) women (65.6 ± 2.8?
Positive_regulation (mediated) of Gene_expression (expression) of melanocortin 3 receptor associated with inflammation and obesity
3) Confidence 0.67 Published 2011 Journal Journal of Aging Research Section Abstract Doc Link PMC3022199 Disease Relevance 0.39 Pain Relevance 0.11
The exposure of mice to cat odour caused only minor changes in the gene expression of wild-type mice, whereas in homozygous animals a significantly increased expression of the Mc3r gene in the frontal cortex and temporal lobe, and the Pomc1 gene in the temporal lobe, mesencephalon and mesolimbic area was established.
Positive_regulation (increased) of Gene_expression (expression) of Mc3r in temporal lobe associated with urological neuroanatomy
4) Confidence 0.49 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16488027 Disease Relevance 0.28 Pain Relevance 0.11
MC3R KO mice also express increased IL-1?
Positive_regulation (increased) of Gene_expression (express) of MC3R
5) Confidence 0.48 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.50 Pain Relevance 0.71
Thus, it is important to note that while the EX subjects in the current study tended to experience an increase in IL-10 mRNA expression and had increased expression of the MC3R, they did not experience significant alterations in body weight or composition.
Positive_regulation (increased) of Gene_expression (expression) of MC3R in body associated with body weight
6) Confidence 0.48 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.05 Pain Relevance 0.47
These results are provocative given that there was a slight increase in IL-10 mRNA coupled with a significant increase in MC3R gene expression without a concomitant change in leukocyte number and a reduction in monocyte number.
Positive_regulation (increase) of Gene_expression (expression) of MC3R gene in monocyte
7) Confidence 0.45 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.59 Pain Relevance 0.17
Specifically, our results are the first to suggest that chronic resistance training may be involved in increasing MC3R gene expression in human whole blood.
Positive_regulation (increasing) of Gene_expression (expression) of MC3R gene in blood
8) Confidence 0.45 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.49 Pain Relevance 0.11
The exposure of mice to cat odour caused only minor changes in the gene expression of wild-type mice, whereas in homozygous animals a significantly increased expression of the Mc3r gene in the frontal cortex and temporal lobe, and the Pomc1 gene in the temporal lobe, mesencephalon and mesolimbic area was established.
Positive_regulation (increased) of in frontal cortex Gene_expression (expression) of Mc3r in temporal lobe associated with urological neuroanatomy
9) Confidence 0.23 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16488027 Disease Relevance 0.28 Pain Relevance 0.11
The exposure of mice to cat odour caused only minor changes in the gene expression of wild-type mice, whereas in homozygous animals a significantly increased expression of the Mc3r gene in the frontal cortex and temporal lobe, and the Pomc1 gene in the temporal lobe, mesencephalon and mesolimbic area was established.
Positive_regulation (increased) of in frontal cortex Gene_expression (expression) of Mc3r in temporal lobe associated with urological neuroanatomy
10) Confidence 0.17 Published 2006 Journal Behav. Brain Res. Section Abstract Doc Link 16488027 Disease Relevance 0.28 Pain Relevance 0.11

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