INT133688

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.03
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdk2) microtubule organizing center (Cdk2) cytoplasm (Cdk2)
cytosol (Cdk2) mitosis (Cdk2) nucleus (Cdk2)
Anatomy Link Frequency
neuronal 1
Cdk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 33 93.16 High High
cINOD 2 91.64 High High
Kinase C 3 85.84 High High
antagonist 18 61.36 Quite High
COX2 1 25.00 Low Low
agonist 7 15.12 Low Low
Central nervous system 13 5.00 Very Low Very Low Very Low
Hippocampus 13 5.00 Very Low Very Low Very Low
adenocard 12 5.00 Very Low Very Low Very Low
Neurotransmitter 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 2 97.24 Very High Very High Very High
Transient Ischemic Attack 1 93.16 High High
INFLAMMATION 10 91.16 High High
Stroke 27 84.40 Quite High
Apoptosis 14 75.00 Quite High
Cervical Cancer 3 75.00 Quite High
Cv Unclassified Under Development 22 74.04 Quite High
Death 29 61.52 Quite High
Cancer 8 60.36 Quite High
Lung Cancer 1 8.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, to illustrate the scaffold hopping capacities of wwLigCSRre, we ran a quick run using the co-crystallized ligand of PDB structure 1E9H (a CDK2 inhibitor) as the query on 47 diversified ligands including 9 CDK2, 9 coagulation factor Xa, 10 neuraminidase, 8 ribonuclease and 10 thymidine kinase inhibitors.
Negative_regulation (inhibitor) of CDK2
1) Confidence 0.31 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2703967 Disease Relevance 0 Pain Relevance 0
Example of scaffold hopping on CDK2 inhibitors
Negative_regulation (inhibitors) of CDK2
2) Confidence 0.31 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2703967 Disease Relevance 0 Pain Relevance 0
Finally, to illustrate the scaffold hopping capacities of wwLigCSRre, we ran a quick run using the co-crystallized ligand of PDB structure 1E9H (a CDK2 inhibitor) as the query on 47 diversified ligands including 9 CDK2, 9 coagulation factor Xa, 10 neuraminidase, 8 ribonuclease and 10 thymidine kinase inhibitors.
Negative_regulation (inhibitors) of CDK2
3) Confidence 0.23 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2703967 Disease Relevance 0 Pain Relevance 0
Finally, to illustrate the scaffold hopping capacities of wwLigCSRre, we ran a quick run using the co-crystallized ligand of PDB structure 1E9H (a CDK2 inhibitor) as the query on 47 diversified ligands including 9 CDK2, 9 coagulation factor Xa, 10 neuraminidase, 8 ribonuclease and 10 thymidine kinase inhibitors.
Negative_regulation (inhibitor) of CDK2
4) Confidence 0.23 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2703967 Disease Relevance 0 Pain Relevance 0
(S)-roscovitine indeed potently inhibits CDK1, CDK2, CDK7, CDK9 [37], as well as Erk1/Erk2 and CK1 [30], that play key roles in neuronal development and survival [38].
Negative_regulation (inhibits) of CDK2 in neuronal
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.39 Pain Relevance 0.08
It has been reported that p44/42 MAPK phosphorylation is essential and sufficient for the increase in cdk2 [188, 189] and decrease in p27Kip1 expression [190, 191].
Negative_regulation (decrease) of cdk2
6) Confidence 0.15 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.06 Pain Relevance 0.12
The G1 arrest is preceded by suppression of cyclin E and A, inactivation of cdk2, and the complete loss of the viral oncoprotein E7, despite ongoing HPV transcription.
Negative_regulation (inactivation) of cdk2 associated with papillomavirus infection
7) Confidence 0.07 Published 2007 Journal Cancer Lett. Section Abstract Doc Link 16488075 Disease Relevance 0.59 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox