INT13370

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.05
Pain Relevance 5.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn4a)
Anatomy Link Frequency
muscle 1
brain 1
oocytes 1
Neuro-2a 1
Body 1
Scn4a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 2 100.00 Very High Very High Very High
Nav1.7 1 100.00 Very High Very High Very High
agonist 1 100.00 Very High Very High Very High
sodium channel 13 99.96 Very High Very High Very High
opiate 4 99.32 Very High Very High Very High
antagonist 14 98.76 Very High Very High Very High
local anesthetic 3 98.04 Very High Very High Very High
methadone 3 98.00 Very High Very High Very High
Morphine 6 97.24 Very High Very High Very High
Enkephalin 5 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 32 100.00 Very High Very High Very High
Body Weight 4 99.90 Very High Very High Very High
Hyperalgesia 2 92.80 High High
Pain 4 90.32 High High
Nociception 1 84.92 Quite High
Neuroblastoma 3 84.48 Quite High
Ganglion Cysts 1 82.04 Quite High
Weight Loss 4 81.08 Quite High
Galactorrhea 1 71.96 Quite High
Apoptosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor.
Negative_regulation (Inhibition) of Nav1.4 associated with analgesic, sodium channel, nav1.7 and local anesthetic
1) Confidence 0.57 Published 2006 Journal J. Neurophysiol. Section Title Doc Link 16807347 Disease Relevance 0.08 Pain Relevance 0.68
-tubulin and microtubule- associated protein 1B (MAP 1B) was dramatically reduced in Neuro-2a-Ng cells compared to control.
Negative_regulation (reduced) of micro in Neuro-2a
2) Confidence 0.41 Published 2007 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC1865092 Disease Relevance 0.16 Pain Relevance 0.11
State-dependent block of rat Nav1.4 sodium channels expressed in xenopus oocytes by pyrazoline-type insecticides.
Negative_regulation (block) of Nav1.4 in oocytes associated with sodium channel
3) Confidence 0.41 Published 2005 Journal Neurotoxicology Section Title Doc Link 15935211 Disease Relevance 0.08 Pain Relevance 0.52
The inclusion of competitors in these assays revealed a decrease in both mu1 and mu2 receptors.
Negative_regulation (decrease) of mu1
4) Confidence 0.17 Published 1988 Journal Life Sci. Section Abstract Doc Link 2848168 Disease Relevance 0 Pain Relevance 0.43
Selective blockade of mu 1 (high affinity) opiate receptor with the irreversible antagonist naloxazone reduced morphine-induced peak concentrations of prolactin by 80 percent while increasing peak growth hormone levels by 250 percent.
Negative_regulation (blockade) of mu 1 associated with antagonist, opiate and morphine
5) Confidence 0.10 Published 1982 Journal Science Section Abstract Doc Link 6285470 Disease Relevance 0 Pain Relevance 0.66
Naloxone (2.0 mg/kg, i.v.) was employed as a broad spectrum opioid antagonist, whereas beta-funaltrexamine (beta-FNA, 1.0-5.0 micrograms, i.c.v.), naloxonazine (NAZ, 20 mg/kg, i.v.) and nor-binaltorphimine (nor-BNI, 4.0-16.0 micrograms, i.c.v.) were used to block mu, mu 1 and kappa receptor sites, respectively.
Negative_regulation (block) of mu 1 associated with antagonist, narcan and opioid
6) Confidence 0.05 Published 1991 Journal Brain Res. Section Abstract Doc Link 1667901 Disease Relevance 0.07 Pain Relevance 0.61
Finally, as in cloned brain NaIIA Na+ channels, batrachotoxin abolished both fast and slow inactivation of mu1 Na+ channels.
Negative_regulation (inactivation) of mu1 in brain
7) Confidence 0.03 Published 1996 Journal Pflugers Arch. Section Abstract Doc Link 8764971 Disease Relevance 0 Pain Relevance 0.09
Methadone is of particular interest because it possesses both micro-receptor agonist and N-methyl-d-aspartate receptor antagonist activities.
Negative_regulation (possesses) of micro-receptor associated with antagonist and agonist
8) Confidence 0.03 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17325516 Disease Relevance 0.42 Pain Relevance 1.44
Slow inactivation of muscle mu1 Na+ channels in permanently transfected mammalian cells.
Negative_regulation (inactivation) of mu1 in muscle
9) Confidence 0.02 Published 1996 Journal Pflugers Arch. Section Title Doc Link 8764971 Disease Relevance 0 Pain Relevance 0.12
Body weight was reduced following chronic mu (lean: 42 g; obese: 49 g), mu1 (lean: 71 g; obese: 38 g), kappa1 (lean: 30 g; obese 14 g), delta1 (lean: 43 g; obese: 22 g) or delta2 (lean: 37.5 g; obese: 36 g) antagonism.
Negative_regulation (reduced) of mu1 in Body associated with body weight and obesity
10) Confidence 0.02 Published 1997 Journal Peptides Section Abstract Doc Link 9396062 Disease Relevance 1.59 Pain Relevance 0.41
Overall food intake was reduced following chronic mu (lean: 8.8 g; obese: 16.1 g), mu1 (lean: 12.6 g; obese: 17.0 g), kappa1 (lean: 6.5 g; obese 7.0 g), delta1 (lean: 9.7 g; obese: 11.1 g) or delta2 (lean: 9.4 g; obese: 14.3 g) antagonism.
Negative_regulation (reduced) of mu1 associated with obesity
11) Confidence 0.02 Published 1997 Journal Peptides Section Abstract Doc Link 9396062 Disease Relevance 1.64 Pain Relevance 0.40

General Comments

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