INT133703

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.85
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
PC-12 2
brain 2
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 6 100.00 Very High Very High Very High
agonist 6 99.82 Very High Very High Very High
Kappa opioid receptor 2 99.66 Very High Very High Very High
Analgesic 2 99.16 Very High Very High Very High
Dopamine 239 98.68 Very High Very High Very High
Intracerebroventricular 2 98.08 Very High Very High Very High
Eae 2 91.04 High High
intrathecal 2 87.92 High High
Opioid 5 85.92 High High
antinociception 2 82.88 Quite High
Disease Link Frequency Relevance Heat
Tics 10 98.18 Very High Very High Very High
Pheochromocytoma 2 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain.
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of Thr in brain associated with analgesic, agonist, kappa opioid receptor and cocaine
1) Confidence 0.19 Published 2007 Journal Brain Res. Bull. Section Title Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.81
Nonetheless, during transient dopamine inputs alone, the loop acts as a sink, in which binding of PKAc to PP2A or phosphoThr75 actually decreases the amount of free PKAc, and thereby decreases the ability of PKAc to phosphorylate DARPP-32 on Thr34.
Negative_regulation (decreases) of Phosphorylation (phosphorylate) of Thr34 associated with dopamine
2) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.08
Similarly, PFR(Tic)amide, a 'super-agonist' of NPFF receptors, inhibited the production of cAMP and slightly decreased DARPP-32/Thr34 phosphorylation in PC-12/rNPFF1 cells.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Thr34 in PC-12 associated with tics and agonist
3) Confidence 0.03 Published 2006 Journal Peptides Section Abstract Doc Link 16490283 Disease Relevance 0.43 Pain Relevance 0.42
If the level of PP2B is decreased to 10% of control (simulating the effect of cyclosporin A for 20 min [27]), the effect of calcium on Thr34 phosphorylation is eliminated.
Negative_regulation (eliminated) of Phosphorylation (phosphorylation) of Thr34
4) Confidence 0.03 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.17
FMRFamide also inhibited DARPP-32/Thr34 phosphorylation in the presence of forskolin.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Thr34
5) Confidence 0.02 Published 2006 Journal Peptides Section Abstract Doc Link 16490283 Disease Relevance 0.41 Pain Relevance 0.40

General Comments

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