INT133729

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.96
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL) cell adhesion (ITGAL) plasma membrane (ITGAL)
Anatomy Link Frequency
cervix 6
myometrium 2
leukocytes 2
Neutrophils 2
T-cells 2
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 136 86.16 High High
Inflammation 59 66.56 Quite High
cytokine 85 65.68 Quite High
Migraine 2 50.00 Quite Low
Inflammatory response 11 43.48 Quite Low
chemokine 13 11.84 Low Low
Infliximab 30 5.00 Very Low Very Low Very Low
Etanercept 26 5.00 Very Low Very Low Very Low
Adalimumab 16 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 33 98.34 Very High Very High Very High
Pressure And Volume Under Development 49 96.78 Very High Very High Very High
Hypersensitivity 12 96.18 Very High Very High Very High
Disease 37 96.04 Very High Very High Very High
Death 1 90.12 High High
Psoriasis 152 86.16 High High
Cv General 4 Under Development 4 81.60 Quite High
Necrosis 6 68.08 Quite High
Cancer 6 67.72 Quite High
INFLAMMATION 68 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-CD11a antibody: Efalizumab: LFA-1, a heterodimer of CD11a and CD18, is a member of the ?
Positive_regulation (-) of Gene_expression (antibody) of CD11a
1) Confidence 0.49 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.56 Pain Relevance 0.16
The interpretation of allergic/atopic predisposition in POEE risk was indicated by our recent observation of elevated leukocyte function asscoiated molecule-1 (LFA-1) expression on leukocytes of at risk patients [18], as LFA-1 expression is increased on leukocytes of atopic children [36].
Positive_regulation (increased) of Gene_expression (expression) of LFA-1 in leukocytes associated with pressure and volume under development and hypersensitivity
2) Confidence 0.20 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 1.14 Pain Relevance 0.03
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (demonstrated) of Gene_expression (expression) of CD11a in cervix associated with adhesions
3) Confidence 0.11 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
Neutrophils from labouring women showed a significantly higher surface expression of CD11a and CD11b (P = 0.001) and CD62L (P < 0.02) compared with the non-labouring women.
Positive_regulation (showed) of Gene_expression (expression) of CD11a in Neutrophils
4) Confidence 0.11 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (increased) of Gene_expression (expression) of CD11a in cervix associated with adhesions
5) Confidence 0.11 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
Anti-CD11a antibody: Efalizumab: LFA-1, a heterodimer of CD11a and CD18, is a member of the ?
Positive_regulation (-) of Gene_expression (Anti) of LFA-1
6) Confidence 0.04 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792605 Disease Relevance 0.56 Pain Relevance 0.16
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (increased) of in myometrium Gene_expression (expression) of CD11a in cervix associated with adhesions
7) Confidence 0.04 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
Neutrophil and monocyte adhesion to myometrial and cervical endothelium will be promoted during parturition by the increased CD11a and CD11b expression which we demonstrated: CD11a and b mediate binding to ICAM-1, which we previously showed was up-regulated in endothelium of human cervix and myometrium during labour (Ledingham et al., 2001).
Positive_regulation (demonstrated) of in myometrium Gene_expression (expression) of CD11a in cervix associated with adhesions
8) Confidence 0.04 Published 2009 Journal Molecular Human Reproduction Section Body Doc Link PMC2762373 Disease Relevance 0.10 Pain Relevance 0.03
The proportion of CD4+ and CD8+ T-cells expressing high levels of LFA-1 showed instead a progressive down-regulation with significantly lower percentages at 2 and 4 hours after attack onset (P < .01 and <.022, respectively).
Positive_regulation (levels) of Gene_expression (expressing) of LFA-1 in T-cells
9) Confidence 0.03 Published 2006 Journal Headache Section Body Doc Link 16492228 Disease Relevance 0.21 Pain Relevance 0

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