INT133743

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.20
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcan) extracellular region (Vcan) proteinaceous extracellular matrix (Vcan)
Anatomy Link Frequency
extracellular matrix 1
Vcan (Mus musculus)
Pain Link Frequency Relevance Heat
carpal tunnel syndrome 5 99.28 Very High Very High Very High
Sciatic nerve 150 93.84 High High
withdrawal 15 93.44 High High
Spinal cord 45 81.92 Quite High
dorsal root ganglion 93 71.20 Quite High
Dorsal column 81 59.68 Quite High
Peripheral nerve injury 15 58.44 Quite High
Inflammation 1 25.00 Low Low
halothane 9 5.00 Very Low Very Low Very Low
unmyelinated 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 237 100.00 Very High Very High Very High
Carpal Tunnel Syndrome 5 99.28 Very High Very High Very High
Pathologic Constriction 1 96.84 Very High Very High Very High
Pressure And Volume Under Development 1 94.76 High High
Nervous System Injury 45 93.20 High High
Cicatrix 12 82.92 Quite High
Injury 141 80.64 Quite High
Ganglion Cysts 96 71.20 Quite High
Disease 1 63.52 Quite High
Neointima 1 42.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, elimination of the NG2 gene may have induced upregulation of other molecules with similar functions during development, thus further compensating for any effects of the absence of NG2 in the knockout animals.
Regulation (effects) of NG2 associated with targeted disruption
1) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.48 Pain Relevance 0.04
Whether or not NG2 has an insignificant role in preventing axonal regeneration in the CNS – as our findings suggest – or is a contributory factor in this process, NG2 is upregulated in vigorously regenerating peripheral.
Neg (not) Regulation (upregulated) of NG2
2) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.23 Pain Relevance 0.10
(calculated using a two tailed Fisher exact test because all 6 NG2 knockout mice recovered on the same day); Fig. 5b).
Regulation (recovered) of NG2 associated with targeted disruption
3) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.78 Pain Relevance 0.40
To clarify the role of tenascin-C and PG-M/versican, which have often been found to be involved in tissue remodeling and vascular stenosis in the pathogenesis of CTS, we histologically and biochemically examined the production of extracellular matrix in the flexor tenosynovium from 40 idiopathic CTS patients.
Regulation (role) of PG-M/versican in extracellular matrix associated with pathologic constriction and carpal tunnel syndrome
4) Confidence 0.07 Published 2006 Journal Histol. Histopathol. Section Abstract Doc Link 16493581 Disease Relevance 0.71 Pain Relevance 0.46

General Comments

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