INT133744

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 10.64
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcan) extracellular region (Vcan) proteinaceous extracellular matrix (Vcan)
Anatomy Link Frequency
neurons 5
perineurium 3
neuronal 2
peripheral nerves 2
oligodendrocytes 2
Vcan (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 305 98.44 Very High Very High Very High
Sciatic nerve 1000 96.10 Very High Very High Very High
dorsal root ganglion 620 95.56 Very High Very High Very High
ischemia 81 95.16 Very High Very High Very High
carpal tunnel syndrome 5 85.00 Quite High
5HT 20 83.64 Quite High
Dorsal column 540 81.36 Quite High
agonist 65 70.52 Quite High
Hippocampus 15 57.36 Quite High
Peripheral nerve injury 100 55.56 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1596 100.00 Very High Very High Very High
Injury 1030 99.84 Very High Very High Very High
Chronic Renal Failure 6 98.76 Very High Very High Very High
Cicatrix 86 97.16 Very High Very High Very High
Ganglion Cysts 640 95.56 Very High Very High Very High
Cv Unclassified Under Development 56 95.16 Very High Very High Very High
Acute Liver Failure 68 94.92 High High
Neointima 1 94.16 High High
Disease 24 93.56 High High
Coma 14 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NG2 is expressed by fibroblast-like cells and microvascular pericytes in peripheral [11,15,25], is present at nodes of Ranvier [15,26] and may also be expressed by a subset of non-myelinating Schwann cells [19].
Gene_expression (expressed) of NG2 in Schwann cells
1) Confidence 0.74 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.33 Pain Relevance 0.17
Although NG2, a molecule widely regarded as a potent inhibitor of axonal regeneration, is strongly expressed at injury sites in the CNS, where regeneration is abortive, it is also strongly expressed in injured peripheral nerves, where axonal regeneration is vigorous (e.g. [10,11,15,27]; and see review by [4]).
Gene_expression (expressed) of NG2 in peripheral nerves associated with injury
2) Confidence 0.74 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.57 Pain Relevance 0.03
For example, NG2, tenascin-C and CSPGs other than NG2 are expressed in similar regions of lesion sites in spinal cord (e.g. the meningeal scar) and peripheral nerves (the perineurium and the surface of bands of Von Büngner) [27,34-37].
Gene_expression (expressed) of NG2 in perineurium associated with cicatrix and spinal cord
3) Confidence 0.65 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.53 Pain Relevance 0.05
Third, it is also possible that the neuronal populations investigated in this study were particularly insensitive to NG2.
Gene_expression (insensitive) of NG2 in neuronal
4) Confidence 0.64 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.44 Pain Relevance 0.07
For example, NG2, tenascin-C and CSPGs other than NG2 are expressed in similar regions of lesion sites in spinal cord (e.g. the meningeal scar) and peripheral nerves (the perineurium and the surface of bands of Von Büngner) [27,34-37].
Gene_expression (other) of NG2 in perineurium associated with cicatrix and spinal cord
5) Confidence 0.64 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.52 Pain Relevance 0.05
This includes the recent work of Yang et al. [22] which provides some of the strongest and most direct in vitro evidence that NG2-expressing cells do not inhibit or repel growing/regenerating neurites, and indeed provides both in vitro and in vivo data suggesting the opposite, albeit based heavily on CNS neurons derived from neonatal rather than mature animals (see below).


Gene_expression (expressing) of NG2 in neurons
6) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.51 Pain Relevance 0.11
NG2 is expressed by fibroblast-like cells and microvascular pericytes in peripheral [11,15,25], is present at nodes of Ranvier [15,26] and may also be expressed by a subset of non-myelinating Schwann cells [19].
Gene_expression (expressed) of NG2 in Schwann cells
7) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.34 Pain Relevance 0.18
Moreover, in very recent work, it has been shown that NG2-expressing cells promote neurite outgrowth from hippocampal and neocortical neurons in vitro and that both in vitro and in vivo NG2-expressing cells are preferentially and extensively contacted by axonal growth cones [22], in keeping with earlier evidence that NG2-expressing cells may receive synaptic input from glutamatergic axons [23,24].
Gene_expression (expressing) of NG2 in neurons
8) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.34 Pain Relevance 0.17
It is known that neuronal populations differ in their responsiveness to NG2 in vitro [6,19,20] and in vivo [28], and it is conceivable that (some of) the neuronal populations we examined do not normally express receptors for NG2 and are thus intrinsically less responsive to NG2 than other populations.
Neg (not) Gene_expression (express) of NG2 in neuronal
9) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.37 Pain Relevance 0.07
This evidence is complemented by evidence, from in vivo studies, that NG2 is present at sites at which regenerative growth of axons within or into the CNS is arrested, notably around CNS injury sites and at the dorsal root entry zone (DREZ), where NG2-expressing cells proliferate and accumulate after injury [10-15]; see reviews by Butt et al, 2002 [4], and Nishiyama, 2007 [16].
Gene_expression (expressing) of NG2 in dorsal root associated with injury
10) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.35 Pain Relevance 0.09
Moreover, the peripheral axons of DRG cells in the sciatic nerve regenerate through the prominent cap of NG2-positive cells that forms over the proximal stump following resection of the nerve, and continue to grow along the distal stump in close proximity to NG2-expressing cells [15].
Gene_expression (expressing) of NG2 in DRG associated with dorsal root ganglion and sciatic nerve
11) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.33 Pain Relevance 0.12
We studied axonal regeneration in the PNS and CNS of genetically engineered mice that do not express NG2, and in sex and age matched wild-type controls.
Neg (not) Gene_expression (express) of NG2
12) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2100060 Disease Relevance 0.29 Pain Relevance 0.23
There is also evidence that regenerating CNS axons may grow through regions rich in NG2-expressing cells [14,21].
Gene_expression (expressing) of NG2
13) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.33 Pain Relevance 0.15
This includes the recent work of Yang et al. [22] which provides some of the strongest and most direct in vitro evidence that NG2-expressing cells do not inhibit or repel growing/regenerating neurites, and indeed provides both in vitro and in vivo data suggesting the opposite, albeit based heavily on CNS neurons derived from neonatal rather than mature animals (see below).


Gene_expression (-) of NG2 in neurons
14) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.51 Pain Relevance 0.11
A possible explanation of the effects of the antibody reported in the study of Tan et al. is that they may have resulted from modulation of the behaviour of NG2-expressing cells or cell complexes, rather than by direct blocking of axon/NG2 interactions.


Gene_expression (expressing) of NG2
15) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.23 Pain Relevance 0.12
Moreover, in very recent work, it has been shown that NG2-expressing cells promote neurite outgrowth from hippocampal and neocortical neurons in vitro and that both in vitro and in vivo NG2-expressing cells are preferentially and extensively contacted by axonal growth cones [22], in keeping with earlier evidence that NG2-expressing cells may receive synaptic input from glutamatergic axons [23,24].
Gene_expression (expressing) of NG2 in neurons
16) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.32 Pain Relevance 0.12
Moreover, in very recent work, it has been shown that NG2-expressing cells promote neurite outgrowth from hippocampal and neocortical neurons in vitro and that both in vitro and in vivo NG2-expressing cells are preferentially and extensively contacted by axonal growth cones [22], in keeping with earlier evidence that NG2-expressing cells may receive synaptic input from glutamatergic axons [23,24].
Gene_expression (expressing) of NG2 in neurons
17) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.36 Pain Relevance 0.17
For example, NG2, tenascin-C and CSPGs other than NG2 are expressed in similar regions of lesion sites in spinal cord (e.g. the meningeal scar) and peripheral nerves (the perineurium and the surface of bands of Von Büngner) [27,34-37].
Gene_expression (expressed) of NG2 in perineurium associated with cicatrix and spinal cord
18) Confidence 0.56 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.53 Pain Relevance 0.05
NG2 knockout mice were bred with C57BL/6 wild-type mice (Harlan, UK) to produce a breeding stock of heterozygous mice, the offspring of which were phenotyped as follows.
Gene_expression (produce) of NG2 associated with targeted disruption
19) Confidence 0.56 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2100060 Disease Relevance 0.36 Pain Relevance 0.06
For these reasons, HDF has not been applied routinely in the treatment of chronic renal failure, and is not commonly available in general facilities for the treatment of acute liver failure.
Neg (not) Gene_expression (applied) of HDF in liver associated with chronic renal failure and acute liver failure
20) Confidence 0.55 Published 2010 Journal BMC Emerg Med Section Body Doc Link PMC2898817 Disease Relevance 0.48 Pain Relevance 0.03

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