INT133747

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.90
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COX5A) small molecule metabolic process (COX5A)
Anatomy Link Frequency
neurons 1
knee 1
COX5A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 15 99.82 Very High Very High Very High
COX2 6 99.72 Very High Very High Very High
Perioperative pain 2 99.00 Very High Very High Very High
Inflammation 11 97.96 Very High Very High Very High
tetrodotoxin 1 97.92 Very High Very High Very High
Pain 5 96.80 Very High Very High Very High
aspirin 2 96.60 Very High Very High Very High
Analgesic 9 96.52 Very High Very High Very High
COX-2 inhibitor 1 94.32 High High
Potency 1 90.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.58 Very High Very High Very High
Post Operative Pain 2 99.00 Very High Very High Very High
Pain 6 96.80 Very High Very High Very High
Disease 4 90.40 High High
Female Infertility 1 89.68 High High
Reprotox - General 3 1 84.24 Quite High
Drug Induced Neurotoxicity 2 75.00 Quite High
Stress 1 64.16 Quite High
Rupture 2 32.08 Quite Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-steroidal anti-inflammatory drugs (NSAIDs), widely used due to their analgesic and anti-inflammatory properties, consistently inhibit ovulation in all mammalian species investigated so far, likely due to the inhibition of cyclooxygenase 2 (COX-2), the inducible isoform of COX, that is the rate-limiting enzyme in prostaglandin (PG) synthesis.
Positive_regulation (inducible) of COX associated with inflammation, analgesic, cinod and cox2
1) Confidence 0.49 Published 2006 Journal Histol. Histopathol. Section Abstract Doc Link 16493584 Disease Relevance 0.44 Pain Relevance 0.67
The purpose of the present investigation was to grade the pain and need for rescue medication during the first 4 days after the knee arthroscopy, comparing a conventional nonsteroidal anti-inflammatory drug (NSAID) with a selective cox-II-inhibitor (coxib) as postoperative pain medication.
Positive_regulation (selective) of cox in knee associated with pain, inflammation, cinod and perioperative pain
2) Confidence 0.49 Published 2006 Journal Knee Surg Sports Traumatol Arthrosc Section Abstract Doc Link 16761158 Disease Relevance 0.54 Pain Relevance 1.06
Here, we compared the dopaminergic neuroprotective property of phenidone (a dual COX and LOX inhibitor) with COX or LOX inhibitors including SC-560 (a COX-1 inhibitor), aspirin (a COX-1/2 inhibitor), meloxicam (a preferential COX-2 inhibitor), caffeic acid (a 5-LOX inhibitor), and esculetin (a 5, 12-LOX inhibitor) in our lipopolysaccharide (LPS)-induced PD animal model.
Positive_regulation (dual) of COX associated with aspirin, cox-2 inhibitor and disease
3) Confidence 0.49 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18760329 Disease Relevance 0.66 Pain Relevance 0.29
Cyclooxygenase-2 (COX-2) is an inducible isoform of the COX family of enzymes central to the synthesis of pro-inflammatory prostaglandins.
Positive_regulation (inducible) of COX associated with inflammation
4) Confidence 0.49 Published 2009 Journal Mol. Cell. Biochem. Section Abstract Doc Link 19219624 Disease Relevance 0.26 Pain Relevance 0.38
Silencing of NRF-1 with small interference RNA prevented the depolarization-stimulated up-regulation of Gria2 and COX, and over-expression of NRF-1 rescued neurons from tetrodotoxin-induced down-regulation of Gria2 and COX transcripts.
Positive_regulation (up-regulation) of COX in neurons associated with tetrodotoxin
5) Confidence 0.45 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19166514 Disease Relevance 0 Pain Relevance 0.18

General Comments

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