INT133768

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 10.24
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
brain 3
synovium 3
hip 1
cortex 1
T cells 1
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 152 99.24 Very High Very High Very High
rheumatoid arthritis 355 98.84 Very High Very High Very High
withdrawal 12 97.38 Very High Very High Very High
methadone 6 97.08 Very High Very High Very High
cytokine 23 95.44 Very High Very High Very High
chemokine 20 95.12 Very High Very High Very High
Morphine 6 93.88 High High
narcan 1 92.12 High High
antagonist 4 91.40 High High
Opioid 3 90.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 157 99.24 Very High Very High Very High
Severe Combined Immunodeficiency 175 99.16 Very High Very High Very High
Rheumatoid Arthritis 355 98.84 Very High Very High Very High
Cognitive Disorder 9 98.24 Very High Very High Very High
Apoptosis 260 97.56 Very High Very High Very High
Staphylococcus Infection 128 97.16 Very High Very High Very High
Blister 11 96.92 Very High Very High Very High
Adhesions 15 96.04 Very High Very High Very High
Disease 30 95.72 Very High Very High Very High
Synovitis 10 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: This study analyzes the effects of prolonged administration of methadone and withdrawal on sensorimotor and cognitive performance in mice and explores the associated changes in brain expression of proteins regulating the extrinsic (FasL, Fas, and caspase-8) and the mitochondrial (Bcl-2, Bcl-x(L), Bad, and Bax) apoptotic pathways.
Regulation (regulating) of FasL in brain associated with cognitive disorder, methadone, apoptosis and withdrawal
1) Confidence 0.44 Published 2007 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17384938 Disease Relevance 0.35 Pain Relevance 0.26
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-xL, Bad and Bax) apoptotic pathways, as well as the active fragment of the executioner caspase-3 in the mouse brain.
Regulation (regulating) of FasL in brain associated with apoptosis
2) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.26 Pain Relevance 0.30
Comparative statistical analysis of the effects of Ad-LacZ and Ad-FasL treatments on the weight of RA synovium was performed using the rank sum test.
Regulation (effects) of FasL in synovium associated with rheumatoid arthritis
3) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.76 Pain Relevance 0.19
Determination of the effects of FasL gene transfer on human inflammatory synovium in vivo is an important step in progressing from mouse/rabbit gene therapies to human gene therapy.
Regulation (effects) of FasL gene in synovium associated with inflammation
4) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.47 Pain Relevance 0.48
A significance test for the effects of Ad-LacZ and Ad-FasL treatments on the weight of RA synovium was performed using the rank sum test (n1 = n2 = 10, T1 = 154, T2 = 56, P < 0.005) (Table 1).
Regulation (effects) of FasL in synovium associated with rheumatoid arthritis
5) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.82 Pain Relevance 0.61
RA synovium from the knee, hip, or shoulder joints of six patients were examined for the effects of FasL gene transfer in vivo in SCID mice.


Spec (examined) Regulation (effects) of FasL gene in hip associated with severe combined immunodeficiency and rheumatoid arthritis
6) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.37 Pain Relevance 0.37
Here, we have analyzed the effects of prolonged heroin administration on sensorimotor and cognitive performance in mice, as well as the associated changes in brain expression of proteins regulating the extrinsic (FasL and Fas) and the mitochondrial (Bcl-2, Bcl-X(L), Bad and Bax) apoptotic pathways.
Regulation (regulating) of FasL in brain associated with cognitive disorder and apoptosis
7) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.70 Pain Relevance 0.12
Both the chronic methadone and repeated withdrawal groups showed up-regulation of several pro-apoptotic proteins (FasL, the active fragment of caspase-8, and Bad) in the cortex and hippocampus, indicating activation of both the death-receptor and mitochondrial apoptotic pathways.
Regulation (regulation) of FasL in hippocampus
8) Confidence 0.26 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.08 Pain Relevance 0
This neurotoxic effect was accompanied by up-regulation of the proapoptotic proteins FasL, Fas, and Bad and the active fragments of caspases-8 and -3 in cortical and hippocampal lysates.
Regulation (regulation) of FasL
9) Confidence 0.25 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.50 Pain Relevance 0.59
RA synovium from the knee, hip, or shoulder joints of six patients were examined for the effects of FasL gene transfer in vivo in SCID mice.


Spec (examined) Regulation (effects) of FasL gene in knee associated with severe combined immunodeficiency and rheumatoid arthritis
10) Confidence 0.15 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.37 Pain Relevance 0.37
However, it is still not fully understood what causes the up-regulation of FasL/Fas on keratinocytes, and how the immune system, including T cells found in blister fluid at the onset of disease may regulate this.
Regulation (regulation) of FasL in T cells associated with blister and disease
11) Confidence 0.12 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3018455 Disease Relevance 1.49 Pain Relevance 0.05
Both the chronic methadone and repeated withdrawal groups showed up-regulation of several pro-apoptotic proteins (FasL, the active fragment of caspase-8, and Bad) in the cortex and hippocampus, indicating activation of both the death-receptor and mitochondrial apoptotic pathways.
Regulation (regulation) of FasL in cortex
12) Confidence 0.09 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.08 Pain Relevance 0

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