INT133788

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.49
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
smooth muscle cells 6
brain structures 2
fibroblast 2
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 130 100.00 Very High Very High Very High
B1 receptor 64 100.00 Very High Very High Very High
dexamethasone 44 99.98 Very High Very High Very High
Spinal cord 1 99.84 Very High Very High Very High
antagonist 62 99.52 Very High Very High Very High
cerebral cortex 1 97.96 Very High Very High Very High
Hippocampus 11 97.28 Very High Very High Very High
Thalamus 1 96.76 Very High Very High Very High
amygdala 1 95.80 Very High Very High Very High
Neuropathic pain 2 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 137 100.00 Very High Very High Very High
Asthma 60 100.00 Very High Very High Very High
Targeted Disruption 19 95.76 Very High Very High Very High
Neuropathic Pain 2 95.76 Very High Very High Very High
Depression 58 93.72 High High
Reperfusion Injury 32 79.40 Quite High
Apoptosis 10 75.64 Quite High
Hypothermia 3 72.32 Quite High
Injury 8 65.36 Quite High
Cv Unclassified Under Development 12 62.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the in vivo characterization of the pharmacodynamics of B1R antagonists is hindered by the low level of B1R expression in healthy tissue and the profound species selectivity exhibited by many compounds for the B1R.
Negative_regulation (level) of Gene_expression (expression) of B1R associated with antagonist
1) Confidence 0.58 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.28 Pain Relevance 0.35
We previously have observed that B1R deletion increased HO-1 and decreased MCP-1 expression [27].
Negative_regulation (decreased) of Gene_expression (deletion) of B1R
2) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.45 Pain Relevance 0.46
Dexamethasone reduces inflammation and hyperreactivity in asthmatic airways [40,41], inhibits kinin receptor expression in cultured human airway fibroblast and smooth muscle cells [42,43].
Negative_regulation (inhibits) of Gene_expression (expression) of kinin in smooth muscle cells associated with asthma, inflammation and dexamethasone
3) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.26 Pain Relevance 0.53
Interestingly, basal expression of B1 receptor has been described in spinal cord and some brain structures, such as cerebral cortex, hippocampus, thalamus, hypothalamus, amygdala, and choroid plexus epithelial cells [10,38,39].
Negative_regulation (described) of Gene_expression (expression) of B1 receptor in brain structures associated with b1 receptor, thalamus, hippocampus, amygdala, cerebral cortex and spinal cord
4) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.74 Pain Relevance 0.76
Dexamethasone reduces inflammation and hyperreactivity in asthmatic airways [40,41], inhibits kinin receptor expression in cultured human airway fibroblast and smooth muscle cells [42,43].
Negative_regulation (reduces) of Gene_expression (expression) of kinin in smooth muscle cells associated with asthma, inflammation and dexamethasone
5) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.26 Pain Relevance 0.56
Dexamethasone reduces inflammation and hyperreactivity in asthmatic airways [40,41], inhibits kinin receptor expression in cultured human airway fibroblast and smooth muscle cells [42,43].
Negative_regulation (inhibits) of in fibroblast Gene_expression (expression) of kinin in smooth muscle cells associated with asthma, inflammation and dexamethasone
6) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.26 Pain Relevance 0.53
Dexamethasone reduces inflammation and hyperreactivity in asthmatic airways [40,41], inhibits kinin receptor expression in cultured human airway fibroblast and smooth muscle cells [42,43].
Negative_regulation (reduces) of in fibroblast Gene_expression (expression) of kinin in smooth muscle cells associated with asthma, inflammation and dexamethasone
7) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.26 Pain Relevance 0.56

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