INT133789

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.00
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
central nervous system 2
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 96 100.00 Very High Very High Very High
B1 receptor 44 100.00 Very High Very High Very High
b2 receptor 34 100.00 Very High Very High Very High
Central nervous system 8 99.84 Very High Very High Very High
antagonist 48 99.58 Very High Very High Very High
Inflammation 85 99.52 Very High Very High Very High
Hippocampus 11 93.68 High High
cytokine 47 92.84 High High
Bioavailability 1 91.44 High High
Neuropathic pain 2 86.28 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 29 100.00 Very High Very High Very High
INFLAMMATION 97 99.52 Very High Very High Very High
Reperfusion Injury 64 99.48 Very High Very High Very High
Apoptosis 13 97.92 Very High Very High Very High
Urological Neuroanatomy 1 92.40 High High
Neuropathic Pain 2 86.28 High High
Aggression 2 85.36 High High
Cv Unclassified Under Development 24 84.92 Quite High
Death 12 77.96 Quite High
Pain 4 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even more, the expression of MCP-1 was reduced while HO-1 was up regulated by B1R antagonism, confirming previous observations from our group that showed a similar expression profile in B1KO mice [27].
Regulation (regulated) of Gene_expression (antagonism) of B1R
1) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.06 Pain Relevance 0.54
Pro and anti-inflammatory molecule expression in B1R knockout or antagonism after renal IRI
Regulation (antagonism) of Gene_expression (knockout) of B1R associated with targeted disruption, reperfusion injury and inflammation
2) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.52 Pain Relevance 0.38
The first is a transgenic rat over-expressing the human B1R under the control of the neuronal-specific enolase promoter; we previously reported the utility of this model in assessing human B1R receptor occupancy in the central nervous system of the rat.
Regulation (under) of Gene_expression (expressing) of B1R in central nervous system associated with targeted disruption and central nervous system
3) Confidence 0.27 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497152 Disease Relevance 0.32 Pain Relevance 0.34
Effects of nicotine on airway kinin B1 and B2 receptor mRNA and protein expressions
Regulation (Effects) of Gene_expression (expressions) of kinin associated with nicotine and b2 receptor
4) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.45
We wondered whether the effects of selective kinin B1 receptor antagonists might be related to changes of B1 receptor expression in CNS structures.
Regulation (changes) of Gene_expression (expression) of B1 receptor associated with antagonist, b1 receptor and central nervous system
5) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.09 Pain Relevance 0.68

General Comments

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