INT133792

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.34
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vim) structural molecule activity (Vim) plasma membrane (Vim)
cytoskeleton (Vim) nucleus (Vim) biological_process (Vim)
Anatomy Link Frequency
neuronal 1
neuron 1
Vim (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 1 99.84 Very High Very High Very High
imagery 1 92.92 High High
backache 1 91.56 High High
Glutamate 4 75.00 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 3 99.30 Very High Very High Very High
Neurothekeoma 7 98.12 Very High Very High Very High
Low Back Pain 1 91.56 High High
Cretinism 2 86.76 High High
Intellectual Impairment 1 83.64 Quite High
Benign Tumor 1 76.84 Quite High
Thyroid Disease 2 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This treatment induced hyperphosphorylation of neurofilaments, the neuronal intermediate filament (IF) proteins, of heavy, medium and low molecular weight (NF-H, NF-M and NF-L, respectively) without altering the phosphorylation level of astrocyte IF proteins, glial fibrillary acidic protein (GFAP) and vimentin in cerebral cortex of rats.
Phosphorylation (phosphorylation) of vimentin in neuronal associated with cerebral cortex
1) Confidence 0.32 Published 2008 Journal Neurotoxicology Section Abstract Doc Link 18845185 Disease Relevance 0.30 Pain Relevance 0.16
The tumors had a strong immunoreactivity for vimentin, S-100 protein, and neuron-specific enolase and focal expression of epithelial membrane antigen and phosphorylated neurofilament.
Phosphorylation (phosphorylated) of vimentin in neuron associated with cancer
2) Confidence 0.03 Published 2006 Journal Pathol. Int. Section Abstract Doc Link 16497247 Disease Relevance 1.03 Pain Relevance 0.14

General Comments

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