INT133809

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2007
Negated 0
Speculated 3
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 7.67
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
synovial cells 2
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 198 99.68 Very High Very High Very High
cINOD 115 99.40 Very High Very High Very High
Inflammation 96 98.96 Very High Very High Very High
Osteoarthritis 98 98.44 Very High Very High Very High
rheumatoid arthritis 136 98.16 Very High Very High Very High
Leflunomide 10 96.68 Very High Very High Very High
Inflammatory response 6 94.84 High High
aspirin 60 90.00 High High
agonist 11 88.00 High High
antagonist 2 87.12 High High
Disease Link Frequency Relevance Heat
Endometriosis 252 99.68 Very High Very High Very High
Breast Cancer 137 99.04 Very High Very High Very High
INFLAMMATION 112 99.02 Very High Very High Very High
Frailty 100 98.44 Very High Very High Very High
Cancer 146 98.38 Very High Very High Very High
Rheumatoid Arthritis 136 98.16 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 3 96.48 Very High Very High Very High
Metastasis 21 93.16 High High
Adhesions 28 88.64 High High
Endometriosis (extended) 21 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) and COX selective inhibitors can suppress CYP19 gene expression and decrease aromatase activity.
Negative_regulation (suppress) of Gene_expression (expression) of CYP19 associated with inflammation and cinod
1) Confidence 0.43 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.47 Pain Relevance 0.20
In addition, we do not know whether administered androgens inhibit the enzyme directly (substrate inhibition) or inhibit aromatase gene expression (genomic action) in synovial cells of OA and RA patients.
Spec (whether) Negative_regulation (inhibit) of Gene_expression (expression) of aromatase gene in synovial cells associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.92 Pain Relevance 0.46
Aromatase expression in synovial tissue
Negative_regulation (tissue) of Gene_expression (expression) of Aromatase
3) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.68 Pain Relevance 0.59
How are aromatase inhibitors currently used?
Negative_regulation (inhibitors) of Gene_expression (used) of aromatase
4) Confidence 0.20 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.74 Pain Relevance 0.04
What is an aromatase inhibitor and how does it work?
Negative_regulation (is) of Gene_expression (does) of aromatase
5) Confidence 0.20 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.32 Pain Relevance 0
What is an aromatase inhibitor and how does it work?
Negative_regulation (inhibitor) of Gene_expression (does) of aromatase
6) Confidence 0.20 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.32 Pain Relevance 0
Continuous use of any NSAIDs appears to result, via a local blockade of the COX-2 enzyme, in a reduction in PGE2 and aromatase synthesis.
Negative_regulation (reduction) of Gene_expression (synthesis) of aromatase associated with cinod
7) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797023 Disease Relevance 0.46 Pain Relevance 0.34
Both NSAIDs and COX-selective inhibitors suppress aromatase mRNA expression and enzyme activity in breast cancer cells.
Negative_regulation (suppress) of Gene_expression (expression) of aromatase associated with breast cancer and cinod
8) Confidence 0.11 Published 2006 Journal Minerva Endocrinol. Section Abstract Doc Link 16498361 Disease Relevance 0.68 Pain Relevance 0.29
The same dose of NSAIDs might have a protective effect in ER-positive or PR-positive tumors by acting on an inflammation-related pathway through decreasing COX-2 activity, reducing PGE2 and aromatase synthesis, and decreasing estrogen production.
Negative_regulation (reducing) of Gene_expression (synthesis) of aromatase associated with inflammation, cancer and cinod
9) Confidence 0.09 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797023 Disease Relevance 0.87 Pain Relevance 0.48
Anastrazole represents the fourth generation of aromatase inhibitors.
Negative_regulation (inhibitors) of Gene_expression (generation) of aromatase
10) Confidence 0.07 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721319 Disease Relevance 0.20 Pain Relevance 0.09
It is possible that persistent expression of aromatase and 17?
Spec (possible) Negative_regulation (persistent) of Gene_expression (expression) of aromatase
11) Confidence 0.04 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305339 Disease Relevance 1.00 Pain Relevance 0.26
It is possible that persistent expression of aromatase and 17?
Spec (possible) Negative_regulation (possible) of Gene_expression (expression) of aromatase
12) Confidence 0.04 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305339 Disease Relevance 1.00 Pain Relevance 0.26

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