INT13382

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 11.73
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maob) oxidoreductase activity (Maob)
Anatomy Link Frequency
brain 3
platelet 1
Maob (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 49 100.00 Very High Very High Very High
Nicotine 17 99.00 Very High Very High Very High
Enkephalin 11 97.56 Very High Very High Very High
fluoxetine 4 96.96 Very High Very High Very High
Eae 6 92.24 High High
imagery 16 90.72 High High
adenocard 1 90.28 High High
antidepressant 11 89.68 High High
addiction 42 82.08 Quite High
alcohol 7 81.64 Quite High
Disease Link Frequency Relevance Heat
Nicotine Addiction 1212 99.84 Very High Very High Very High
Parkinson's Disease 125 99.80 Very High Very High Very High
Disease 177 99.20 Very High Very High Very High
Cognitive Disorder 14 94.44 High High
Alzheimer's Dementia 10 92.48 High High
Body Weight 1 90.92 High High
Cancer 24 90.44 High High
Lung Cancer 21 86.92 High High
Pathologic Processes 2 82.32 Quite High
Colon Cancer 7 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On average MAO-B is inhibited by over 40% in smokers vs. non-smokers with no significant difference between brains of non- and ex-smokers.
Negative_regulation (inhibited) of MAO-B in brains associated with nicotine addiction
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.37 Pain Relevance 0
The present results reassert that MAO-B activity is inhibited by smoking and reveal for the first time that (i) platelet MAO-B protein concentration increased during smoking and (ii) this increase lasted long after quitting smoking (13 yrs average in our FS group, Table 2).

5-HT Catabolism and Cardiovascular Risk

Negative_regulation (inhibited) of MAO-B in platelet associated with nicotine addiction
2) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.31 Pain Relevance 0
This was unforeseen since MAO-B activity was inhibited during smoking (P<0.00001).
Negative_regulation (inhibited) of MAO-B associated with nicotine addiction
3) Confidence 0.57 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2775922 Disease Relevance 1.58 Pain Relevance 0.11
The present study supports these conclusions and proposes a mechanism regulating MAO-B inhibition and slow recovery.
Negative_regulation (inhibition) of MAO-B
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.22 Pain Relevance 0.04
Both S and FS exhibited reduced methylation of the MAOB promoter, leading to a more active transcription of the gene and hence a greater protein concentration of MAO-B.
Negative_regulation (reduced) of MAOB associated with nicotine addiction
5) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.15 Pain Relevance 0.19
This inhibition of MAO-B catalytic activity during smoking is also in agreement with PET-scan data obtained with brain [32] and peripheral organs [33] of smokers, non-smokers and ex-smokers using a radiotracer which binds irreversibly to MAO-B.
Negative_regulation (inhibition) of MAO-B in brain associated with nicotine addiction
6) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.34 Pain Relevance 0
The extracts, at the dose of 140 mg/kg or above for 14 days, significantly inhibited the monoamine oxidize A (MAO) activity in mouse whole brain at a dose-dependent manner, however, oral administration of the extract only at a dose of 560 mg/kg produced observable MAO B inhibitory activity in animal brain.
Negative_regulation (produced) of MAO B in brain associated with monoamine
7) Confidence 0.41 Published 2002 Journal J Ethnopharmacol Section Abstract Doc Link 12413724 Disease Relevance 0 Pain Relevance 0.48
In contrast, p-chloro-beta-methylphenethylamine (p-CMP), selectively inhibited MAOB activity, with complete recovery within 45 min after the injection.
Negative_regulation (inhibited) of MAOB
8) Confidence 0.40 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1852266 Disease Relevance 0 Pain Relevance 0.10
Moreover, ex vivo animal experiments showed that tobacco smoke induced a reduction in the MAOB promoter methylation.
Negative_regulation (reduction) of MAOB associated with nicotine addiction
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 1.07 Pain Relevance 0.14
Some central effects of Ro 19-6327--a new MAO-B inhibitor--were studied in mice and rats.
Negative_regulation (inhibitor) of MAO-B
10) Confidence 0.30 Published 1991 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 1668212 Disease Relevance 0.18 Pain Relevance 0.12
[Effects of monoamine oxidase B inhibitor and MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) on enkephalin levels in mice].
Negative_regulation (inhibitor) of monoamine oxidase B associated with parkinson's disease, enkephalin and monoamine
11) Confidence 0.24 Published 1990 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Title Doc Link 2118063 Disease Relevance 0.52 Pain Relevance 0.96
Nicotine is an antioxidant (Ferger et al. 1998) and is an inhibitor of monoamine oxidase B that activates MPTP neuorotoxicity (Yong and Perry 1986).
Negative_regulation (inhibitor) of monoamine oxidase B associated with parkinson's disease, nicotine and monoamine
12) Confidence 0.17 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1280408 Disease Relevance 0.92 Pain Relevance 0.23
For example, using inhibitors of monoamine oxidase B as radiotracers in AD has targeted the elevation of monoamine oxidase B activity [39, 40].
Negative_regulation (inhibitors) of monoamine oxidase B associated with disease and monoamine
13) Confidence 0.15 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 1.07 Pain Relevance 0.35

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