INT133826

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 7.88
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Kdm5d) nucleus (Kdm5d) intracellular (Kdm5d)
DNA binding (Kdm5d)
Anatomy Link Frequency
ganglia 1
Kdm5d (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 61 100.00 Very High Very High Very High
depression 45 100.00 Very High Very High Very High
monoamine 1 99.72 Very High Very High Very High
Arthritis 19 94.20 High High
Pain score 1 94.20 High High
rheumatoid arthritis 122 92.20 High High
backache 2 91.00 High High
visual analogue scale 6 70.00 Quite High
Infliximab 5 63.96 Quite High
Angina 17 60.00 Quite High
Disease Link Frequency Relevance Heat
Pain 60 100.00 Very High Very High Very High
Depression 47 100.00 Very High Very High Very High
Anxiety Disorder 45 100.00 Very High Very High Very High
Rheumatic Diseases 25 99.48 Very High Very High Very High
Disease 143 98.24 Very High Very High Very High
Multiple System Atrophy 11 96.24 Very High Very High Very High
Diabetes Mellitus 91 95.48 Very High Very High Very High
Cold Sores 89 95.04 Very High Very High Very High
Arthritis 19 94.20 High High
Emergencies 3 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, the aim was to take these clinical measures in combination in a single model to predict the EQ-5D index.
Negative_regulation (predict) of EQ-5D
1) Confidence 0.16 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2900231 Disease Relevance 0.69 Pain Relevance 0.12
We used the EQ-5D to calculate QALYs as an assessment of an individual's HRQL according to the following five EQ-5D domains: mobility, self-care, usual activities, pain, and anxiety/depression.
Negative_regulation (depression) of EQ-5D associated with pain, depression and anxiety disorder
2) Confidence 0.12 Published 2010 Journal BMC Geriatr Section Body Doc Link PMC2867806 Disease Relevance 0.52 Pain Relevance 0.15
The distributions of the EQ-5D and 15D scores at 6 months are presented in Fig. 1.
Negative_regulation (presented) of EQ-5D
3) Confidence 0.08 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2981733 Disease Relevance 0 Pain Relevance 0
The pain, disability (von Korff pain and disability scores), ADL (Hannover ADL score), and quality of life (QoL) (EQ-5D) were measured after 3 weeks, and 3, 6, and 12 months.
Negative_regulation (measured) of EQ-5D associated with pain
4) Confidence 0.06 Published 2010 Journal Eur Spine J Section Abstract Doc Link 19760437 Disease Relevance 1.05 Pain Relevance 0.42
In the model, the expected value for the latent utility of each health state is assumed to be a linear function of the categorical ratings on the five EQ-5D domains:
   (4)
Negative_regulation (function) of EQ-5D
5) Confidence 0.04 Published 2003 Journal Popul Health Metr Section Body Doc Link PMC344742 Disease Relevance 0 Pain Relevance 0
Grieve et al. name the absence of a vitality dimension in the EQ-5D as a possible explanation [24].
Spec (possible) Negative_regulation (absence) of EQ-5D
6) Confidence 0.04 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2864208 Disease Relevance 0.17 Pain Relevance 0.04
Revision of EQ-5D domain concepts and child-friendly adaptations
Negative_regulation (Revision) of EQ-5D
7) Confidence 0.03 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2892611 Disease Relevance 0.08 Pain Relevance 0
A known limit of the EQ-5D is to have a 3 responses format, as a consequence subject to a considerable ceiling effect.
Negative_regulation (limit) of EQ-5D
8) Confidence 0.03 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1562359 Disease Relevance 0.16 Pain Relevance 0.08
The reduction in EQ-5D and SF-6D scores would be expected to mirror the gradual increase in burden of disease.


Negative_regulation (reduction) of EQ-5D associated with disease
9) Confidence 0.02 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.41 Pain Relevance 0.14
Recently, some studies were done that compared the EQ-5D and the SF-6D, as in our study [21,24-29].
Negative_regulation (compared) of EQ-5D
10) Confidence 0.02 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1475841 Disease Relevance 0.16 Pain Relevance 0
The positive effect of surgical excision on patient quality of life was demonstrated by a statistically significant difference on the EQ-5D index (p<.001) and the EQ-5D VAS (p<.001).
Negative_regulation (difference) of EQ-5D
11) Confidence 0.02 Published 2010 Journal J Minim Invasive Gynecol Section Body Doc Link 20129331 Disease Relevance 0 Pain Relevance 0
Two recent independent reports confirmed that IE regions of latent HSV-1 are repressed, at least in part, through the deposition of facultative heterochromatin (indicated by triMeH3K27 enrichment) on the IE promoters and this deposition is regulated by LAT [26], [27] and an additional report has also proven that the inhibition of the histone demethylase LSD-1 using monoamine oxidase inhibitors results in the recruitment of repressive histone marks and has the capability of blocking HSV-1 lytic replication and reactivation from latency in vitro and in explanted ganglia [28].
Negative_regulation (inhibition) of histone demethylase LSD-1 in ganglia associated with cold sores and monoamine
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973973 Disease Relevance 0.77 Pain Relevance 0.05
For both VAS and index scores, after adjusting for other characteristics, respondents reported decreasing EQ-5D scores as status moved from low to high risk (-6.49 for VAS score and -0.045 for index score) to a diagnosis of type 2 diabetes (-9.75 for VAS score and -0.054 for index score; p < 0.001 vs. 0–2 RFs for all).


Negative_regulation (decreasing) of EQ-5D associated with diabetes mellitus
13) Confidence 0.01 Published 2008 Journal Health Qual Life Outcomes Section Abstract Doc Link PMC2266905 Disease Relevance 1.08 Pain Relevance 0
In the current NDB study, we found profound impairment in PCS, HAQ, and EQ-5D despite a low estimated DAS28 score.
Negative_regulation (impairment) of EQ-5D associated with rheumatic diseases
14) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888182 Disease Relevance 1.03 Pain Relevance 0.50
In contrast, patients in the SSIC study reported a decrease in the psychological dimension of the EQ-5D, whereas for patients scheduled for various types of surgery this score did not change.
Negative_regulation (decrease) of EQ-5D
15) Confidence 0.00 Published 2010 Journal Qual Life Res Section Body Doc Link PMC2874031 Disease Relevance 0.27 Pain Relevance 0.13
Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired.
Negative_regulation (impaired) of EQ-5D associated with depression
16) Confidence 0.00 Published 2006 Journal Mov. Disord. Section Abstract Doc Link 16502399 Disease Relevance 1.43 Pain Relevance 0.19

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