INT133841

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 9.96
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SOX10) DNA binding (SOX10) cytoplasm (SOX10)
Anatomy Link Frequency
placenta 4
glial cells 2
plasma 1
neural 1
SOX10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 224 97.52 Very High Very High Very High
Central nervous system 138 93.28 High High
Hippocampus 240 92.00 High High
tolerance 16 84.12 Quite High
nMDA receptor 96 76.16 Quite High
Neurobehavioral 32 73.36 Quite High
peripheral neuropathy 1 72.64 Quite High
imagery 32 56.44 Quite High
positron emission tomography 32 50.00 Quite Low
ischemia 16 48.96 Quite Low
Disease Link Frequency Relevance Heat
Hirschsprung Disease 4 99.56 Very High Very High Very High
Injury 352 99.36 Very High Very High Very High
Ulcers 16 99.28 Very High Very High Very High
Shellfish Poisoning 176 99.20 Very High Very High Very High
Duodenal Ulcer 16 98.96 Very High Very High Very High
Convulsion 160 98.92 Very High Very High Very High
Waardenburg Syndrome 5 98.52 Very High Very High Very High
Toxicity 464 98.40 Very High Very High Very High
Hemorrhage 48 98.28 Very High Very High Very High
Pressure And Volume Under Development 112 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuronal expression of SOX10 occurs in neural crest cells during early embryonic development and in glial cells of the peripheral and central nervous systems during late embryonic development and in adults.
Gene_expression (expression) of SOX10 in glial cells
1) Confidence 0.67 Published 2006 Journal Eur. J. Paediatr. Neurol. Section Abstract Doc Link 16504559 Disease Relevance 1.55 Pain Relevance 0.04
The concept of neuroendocrine perturbation by EEAs has been pointed out in the past [143–144] and deserves further considerations in light of new evidence that DOM crosses the placenta and can be detected in milk, opening the both the possibility of a risk of fetal and neonatal exposure [28,40,44,45], and of endocrine disruption effect, which could manifest later in life.


4.

Gene_expression (detected) of DOM in placenta
2) Confidence 0.61 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.64 Pain Relevance 0
These findings raise concern regarding possible increase in the risk of log term effects if DOM exposure occurs during pregnancy and lactation, particularly since it has been demonstrated that DOM crosses the placenta and can be detected in milk [28,40,44,45].
Gene_expression (detected) of DOM in placenta
3) Confidence 0.61 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.40 Pain Relevance 0.05
A recent study provides evidence that DOM is transferable in the milk of lactating rats [45].
Gene_expression (transferable) of DOM
4) Confidence 0.61 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.22 Pain Relevance 0.04
Furthermore, the fact that DOM is transferred to milk opens the possibility of a risk for neonatal exposure by this route.
Gene_expression (transferred) of DOM
5) Confidence 0.61 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.42 Pain Relevance 0.07
There is also evidence that DOM crosses the placenta and can be detected in milk, opening the possibility of a risk for fetal and neonatal exposure [28,40,44,45].
Gene_expression (detected) of DOM in placenta
6) Confidence 0.61 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.59 Pain Relevance 0
The authors show transfer of DOM from spiked milk [0.3 and 1.0 mg/kg] to the plasma of nursing neonatal rats with an overall longer DOM retention in milk than in plasma after 8 hr exposure of the dams.
Gene_expression (transfer) of DOM in plasma
7) Confidence 0.53 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.22 Pain Relevance 0.04
Harmful algal blooms (HABs) appear to be increasing worldwide, including those of the Pseudo-nitzschia species which produce DOM.
Gene_expression (produce) of DOM
8) Confidence 0.53 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.59 Pain Relevance 0
Mussel extract and DOM produced gastric [antral] ulcers, duodenal ulcers, bleeding and ascites [140].
Gene_expression (produced) of DOM associated with pressure and volume under development, duodenal ulcer, ulcers and hemorrhage
9) Confidence 0.53 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.91 Pain Relevance 0.11
There is also evidence that DOM crosses the placenta and can be detected in milk, opening the possibility of a risk for fetal and neonatal exposure [28,40,44,45].
Gene_expression (detected) of DOM in placenta
10) Confidence 0.53 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.59 Pain Relevance 0
Age and gender susceptibility to DOM exposure
Gene_expression (exposure) of DOM
11) Confidence 0.46 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.75 Pain Relevance 0.07
These chronic neuropathology lesions were interpreted as likely due to a combination of DOM exposure and the effect of ongoing seizure activity.
Gene_expression (exposure) of DOM associated with convulsion
12) Confidence 0.46 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.86 Pain Relevance 0.08
Sub-convulsive behavioral abnormal responses were observed in neonatal rats administered daily subcutaneous injections of low doses of DOM [5 and 20 ?
Gene_expression (doses) of DOM
13) Confidence 0.46 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.36 Pain Relevance 0.04
Glial cells are also known targets for DOM effects.
Gene_expression (effects) of DOM in Glial cells
14) Confidence 0.46 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.70 Pain Relevance 0.08
Hence, it remains to be elucidated that the effects of chronic exposure to DOM during gestation or through lactation at doses below or equivalent to the maximal residual limit of 20 ?
Gene_expression (exposure) of DOM
15) Confidence 0.46 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.57 Pain Relevance 0.07
DOM acid was detectable in milk up to 24 hr after exposure [1.0 mg/kg] of the mothers, although the amount of DOM transferred in milk after exposure was not sufficient to cause acute symptoms in neonates.
Gene_expression (detectable) of DOM
16) Confidence 0.41 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.15 Pain Relevance 0.03
DOM is produced by different species of Pseudo- nitzschia [9–13]. and other marine organisms such as the red alga Chondria armata [14DOM can potentially enter the food chain by contaminating shellfish and other types of seafood.
Gene_expression (produced) of DOM
17) Confidence 0.41 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.43 Pain Relevance 0.09
These cells continue to express early neural markers but also begin to express A2B5 and Sox10.
Gene_expression (express) of Sox10 in neural
18) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0 Pain Relevance 0

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