INT133842

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 5.79
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SOX10) DNA binding (SOX10) cytoplasm (SOX10)
Anatomy Link Frequency
brain 2
placenta 1
SOX10 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 24 97.48 Very High Very High Very High
Glutamate 84 96.24 Very High Very High Very High
Hippocampus 90 93.36 High High
nMDA receptor 36 92.76 High High
Glutamate receptor 30 79.04 Quite High
Neurotransmitter 18 76.68 Quite High
excitatory amino acid 18 74.04 Quite High
Limbic system 18 71.60 Quite High
Central nervous system 48 67.92 Quite High
insula 6 65.24 Quite High
Disease Link Frequency Relevance Heat
Toxicity 174 99.96 Very High Very High Very High
Syndrome 26 99.92 Very High Very High Very High
Waardenburg Syndrome 10 99.80 Very High Very High Very High
Demyelinating Disease 8 97.84 Very High Very High Very High
Neuropathic Pain 2 97.28 Very High Very High Very High
"congenital, Hereditary, And Neonatal Diseases And Abnormalities" 2 96.32 Very High Very High Very High
Epilepsy 30 96.20 Very High Very High Very High
Deafness 4 95.44 Very High Very High Very High
Poisoning 138 95.36 Very High Very High Very High
Congenital Anomalies 26 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence indicates that DOM binds to KA subtypes of iGluRs with high affinity, but is a partial agonist [48].
DOM Spec (partial) Binding (binds) of associated with agonist
1) Confidence 0.38 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0 Pain Relevance 0.35
SOX10 mutations are specifically associated with a more severe phenotype called PCWH: peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease.
SOX10 Binding (associated) of associated with hirschsprung disease, neuropathic pain, demyelinating disease and waardenburg syndrome
2) Confidence 0.37 Published 2006 Journal Eur. J. Paediatr. Neurol. Section Abstract Doc Link 16504559 Disease Relevance 1.48 Pain Relevance 0.03
Shah-Waardenburg syndrome and PCWH associated with SOX10 mutations: a case report and review of the literature.
SOX10 Binding (associated) of associated with waardenburg syndrome
3) Confidence 0.37 Published 2006 Journal Eur. J. Paediatr. Neurol. Section Title Doc Link 16504559 Disease Relevance 1.48 Pain Relevance 0.03
These findings raise concern regarding possible increase in the risk of log term effects if DOM exposure occurs during pregnancy and lactation, particularly since it has been demonstrated that DOM crosses the placenta and can be detected in milk [28,40,44,45].
DOM Binding (detected) of in placenta
4) Confidence 0.29 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.40 Pain Relevance 0.05
Despite the differences in species, data collection, history of events and study design there is an overall agreement regarding the histopathology of the brain lesions associated with acute DOM toxicity and its sequels.
DOM Binding (associated) of in brain associated with toxicity
5) Confidence 0.26 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.82 Pain Relevance 0.16
Two separate clinical syndromes are now described in these animals: one associated with acute DOM toxicosis as previously documented, and a second novel neurological syndrome characterized by epilepsy described as a consequence of chronic sub-lethal exposure to the toxin [28].
DOM Binding (associated) of associated with epilepsy and syndrome
6) Confidence 0.26 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.53 Pain Relevance 0
This document includes: 1) a summary of ASP, 2) a review of the pathology associated with DOM toxicity including highlights and illustrations of some key neuropathology features, 3) illustration and description of the ultra structural changes observed in rat hippocampus associated to subchronic oral exposure [81–83], 4) age and gender susceptibility, 5) overview of key mechanisms of cell/tissue injury in relation to DOM induced brain pathology, 6) considerations relevant to food safety and human health.

2.

DOM Binding (associated) of in brain associated with toxicity, brain disease, injury and hippocampus
7) Confidence 0.25 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.59 Pain Relevance 0.34
Specific control measures have been implemented in Canada and around the world to prevent food-borne illness associated with DOM in bivalves [22–23].
DOM Binding (associated) of
8) Confidence 0.25 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525487 Disease Relevance 0.50 Pain Relevance 0.07

General Comments

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