INT133846

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 11.52
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (NPPB) extracellular region (NPPB) nucleus (NPPB)
cytoplasm (NPPB)
Anatomy Link Frequency
plasma 2
cardiomyocytes 1
vessels 1
heart 1
NPPB (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 41 100.00 Very High Very High Very High
anesthesia 5 97.20 Very High Very High Very High
Inflammation 73 94.24 High High
Angina 79 80.32 Quite High
ischemia 41 63.84 Quite High
cytokine 25 61.48 Quite High
Inflammatory response 13 47.48 Quite Low
imagery 16 36.48 Quite Low
cva 8 5.00 Very Low Very Low Very Low
Catecholamine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 133 100.00 Very High Very High Very High
Diabetes Mellitus 107 99.84 Very High Very High Very High
Myocardial Infarction 271 99.56 Very High Very High Very High
Stress 35 99.56 Very High Very High Very High
Death 88 99.16 Very High Very High Very High
Brain Hemorrhage 65 98.68 Very High Very High Very High
Infarction 18 96.64 Very High Very High Very High
Vascular Disease 3 96.40 Very High Very High Very High
Natriuresis 88 96.28 Very High Very High Very High
Arrhythmias 2 Under Development 68 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So, our study aimed to further explore the association between elevated BMI and NT-proBNP in diabetes and the relationship of echocardiographic indexes of increased left ventricular (LV) filling pressure, LV geometry and atherosclerosis as measured by common carotid intima-media thickness (CCIMT).


NT-proBNP Binding (association) of associated with diabetes mellitus, obesity and increased venous pressure under development
1) Confidence 0.42 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 2.13 Pain Relevance 0.08
Although plasma levels are affected by a variety of physiological factors, BNP and especially its cleaved N-terminal pro-BNP (NT-proBNP) have been shown to be reliable serum markers for impaired cardiac function.
NT-proBNP Binding (cleaved) of in plasma
2) Confidence 0.37 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.76 Pain Relevance 0.10
Although plasma levels are affected by a variety of physiological factors, BNP and especially its cleaved N-terminal pro-BNP (NT-proBNP) have been shown to be reliable serum markers for impaired cardiac function.
N-terminal pro-BNP Binding (cleaved) of in plasma
3) Confidence 0.37 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.75 Pain Relevance 0.10
Even after adjusting for age, gender, diabetes, creatinine, ejection fraction and E/Ea in multivariate linear regression analysis, LV mass index was significantly associated with NT-proBNP (r=0.57, p=0.03) (Table 3).


NT-proBNP Binding (associated) of associated with diabetes mellitus
4) Confidence 0.35 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 1.60 Pain Relevance 0
Recently, BNP has been related with coronary vessels involvement showing a significant correlation with left descending artery disease and TIMI flow.20 In another report, BNP appeared associated with multivessels disease in ACS patients without systolic dysfunction.21
BNP Spec (appeared) Binding (related) of in vessels associated with acute coronary syndrome, vascular disease and disease
5) Confidence 0.23 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.17 Pain Relevance 0.18
Recently BNP and pro-BNP are entered in clinical practice to recognize patients at major risk, providing incremental information respect to the traditional markers.
BNP Binding (recognize) of
6) Confidence 0.22 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2716777 Disease Relevance 0.62 Pain Relevance 0.05
Recently BNP and pro-BNP are entered in clinical practice to recognize patients at major risk, providing incremental information respect to the traditional markers.
BNP Binding (recognize) of
7) Confidence 0.22 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2716777 Disease Relevance 0.62 Pain Relevance 0.05
The additional further research on the role that the interaction between these serum markers such as LPA, Hcy and BNP played in the prevalence of the SBI was desirable.
BNP Binding (interaction) of associated with brain hemorrhage
8) Confidence 0.19 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.02 Pain Relevance 0
Secreted by the ventricles in response to cardiomyocytes under tension [27], BNP binds and activates receptors causing reduction in systemic vascular resistance, central venous pressure and natriuresis.
BNP Binding (binds) of in cardiomyocytes associated with natriuresis
9) Confidence 0.17 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.91 Pain Relevance 0
They found that patients with high NT-proBNP values had a lower event rate with tirofiban treatment compared to placebo at 48 h, they found no significant interaction between NT-proBNP values and the clinical benefit of tirofiban treatment at 30 days.
NT-proBNP Neg (no) Binding (interaction) of
10) Confidence 0.15 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.71 Pain Relevance 0.03
Although NTproBNP, TIMP1 and MMP 9 were associated with cardiovascular death, heart failure or both, they were not associated with re-infarction [108].
NTproBNP Binding (associated) of in heart associated with metalloproteinase, infarction, myocardial infarction and death
11) Confidence 0.15 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.95 Pain Relevance 0.21
Adjusted for age, previous myocardial infarction, preoperative fibrinogen, creatinine, high-sensitivity C-reactive protein, type, duration, and surgical complications, only postoperative NT-proBNP remained significantly associated with in-hospital (adjusted hazard ratio, 19.8; 95% confidence interval, 3.4-115) and long-term cardiac outcome (adjusted hazard ratio, 4.88; 95% confidence interval, 2.43-9.81).
NT-proBNP Binding (associated) of
12) Confidence 0.04 Published 2007 Journal Anesthesiology Section Body Doc Link 17525582 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Preoperative N-terminal pro-BNP (NT-proBNP) is independently associated with adverse cardiac outcome but does not anticipate the dynamic consequences of anesthesia and surgery.
NT-proBNP Binding (associated) of associated with anesthesia
13) Confidence 0.04 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17525582 Disease Relevance 0.07 Pain Relevance 0.10
BACKGROUND: Preoperative N-terminal pro-BNP (NT-proBNP) is independently associated with adverse cardiac outcome but does not anticipate the dynamic consequences of anesthesia and surgery.
N-terminal pro-BNP Binding (associated) of associated with anesthesia
14) Confidence 0.04 Published 2007 Journal Anesthesiology Section Abstract Doc Link 17525582 Disease Relevance 0.07 Pain Relevance 0.10
CONCLUSIONS: NT-proBNP is associated with clinically significant coronary disease at angiography, independently of left ventricular dysfunction.
NT-proBNP Binding (associated) of
15) Confidence 0.03 Published 2006 Journal Am. Heart J. Section Body Doc Link 16504637 Disease Relevance 0.06 Pain Relevance 0

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