INT13385

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Context Info
Confidence 0.76
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 60
Total Number 62
Disease Relevance 41.86
Pain Relevance 6.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
brain 3
neuronal 2
tail 1
epithelium 1
substantia nigra pars compacta 1
Bad (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 63 100.00 Very High Very High Very High
Analgesic 6 100.00 Very High Very High Very High
monoamine 1 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
Intracerebroventricular 1 99.52 Very High Very High Very High
tail-flick 1 98.88 Very High Very High Very High
Substantia nigra 1 98.48 Very High Very High Very High
Antinociceptive 2 98.40 Very High Very High Very High
aspirin 9 97.60 Very High Very High Very High
ischemia 17 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Prostate Cancer 1346 100.00 Very High Very High Very High
Apoptosis 1308 100.00 Very High Very High Very High
Cancer 1156 99.84 Very High Very High Very High
Neurodegenerative Disease 66 99.52 Very High Very High Very High
Targeted Disruption 25 99.44 Very High Very High Very High
Cognitive Disorder 21 98.70 Very High Very High Very High
Sprains And Strains 21 98.60 Very High Very High Very High
Hypoxia 39 98.08 Very High Very High Very High
Cv Unclassified Under Development 15 97.20 Very High Very High Very High
Breast Cancer 91 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BAD expression stimulates prostate tumor growth
Gene_expression (expression) of BAD associated with prostate cancer
1) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.66 Pain Relevance 0.03
This connection between BAD expression and proliferation provides a possible explanation for an increase in expression of phosphorylated BAD protein in prostate tumors.
Gene_expression (expression) of BAD protein associated with prostate cancer
2) Confidence 0.76 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.76 Pain Relevance 0
Calcitriol treatment also suppresses the phosphorylation of Akt and the expression of Bcl-2 family member BAD 64.
Gene_expression (expression) of BAD
3) Confidence 0.75 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.82 Pain Relevance 0.05
In contrast, reduced expression of the apoptosis regulatory proteins FasL and Bad was found after a single administration of methadone.
Gene_expression (expression) of Bad
4) Confidence 0.68 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.07 Pain Relevance 0
Although both increased proliferation and glycolysis are hallmarks of tumor growth, the experimental evidence that connects BAD expression with tumor growth has been lacking.
Gene_expression (expression) of BAD associated with cancer
5) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.61 Pain Relevance 0.06
Experiments in tissue culture have shown that expression of BAD stimulates division of prostate cancer cells as well as other cancer cells.
Gene_expression (expression) of BAD associated with cancer and prostate cancer
6) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.69 Pain Relevance 0.03
Several reports have shown that cells that express BAD proliferate faster; however, mechanistic details on how BAD promotes proliferation diverge.
Gene_expression (express) of BAD
7) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.66 Pain Relevance 0.07
To determine whether increased expression levels of BAD stimulate prostate tumor growth in vivo, we compared growth of C4-2Luc and C4-2LucBAD cells implanted in immunocompromised mice.
Gene_expression (expression) of BAD associated with prostate cancer
8) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.83 Pain Relevance 0.04
Therefore, we examined the effect of knocking down BAD expression on proliferation of these cells.
Gene_expression (expression) of BAD
9) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.63 Pain Relevance 0
This connection between BAD expression and proliferation provides a possible explanation for an increase in expression of phosphorylated BAD protein in prostate tumors.
Gene_expression (expression) of BAD associated with prostate cancer
10) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.76 Pain Relevance 0
It is also possible that by increasing rate of glucose utilization, BAD expression provides competitive advantage to the cells in hypoxic tumors that switch from oxidative phosphorylation to glycolysis [23].
Gene_expression (expression) of BAD associated with cancer and hypoxia
11) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.69 Pain Relevance 0.08
Reduced expression of BAD led to decreased proliferation of C4-2 cells (Fig. 1D, E).


Gene_expression (expression) of BAD
12) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.70 Pain Relevance 0.03
These findings were extended to T cells by showing that T-cells over-expressing BAD were more likely to remain in S-phase [19].
Gene_expression (expressing) of BAD in T-cells
13) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.76 Pain Relevance 0
A recent study has shown that BAD expression is elevated in prostatic carcinomas compared to low expression in normal prostatic epithelium [13].
Gene_expression (expression) of BAD in epithelium associated with prostate cancer
14) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.35 Pain Relevance 0.08
Expression of the Bcl-2 Protein BAD Promotes Prostate Cancer Growth

BAD, a pro-apoptotic protein of the Bcl-2 family, has recently been identified as an integrator of several anti-apoptotic signaling pathways in prostate cancer cells.

Gene_expression (Expression) of BAD associated with prostate cancer and apoptosis
15) Confidence 0.59 Published 2009 Journal PLoS ONE Section Title Doc Link PMC2704953 Disease Relevance 1.29 Pain Relevance 0
Analysis of the effect of BAD on prostate cancer xenografts has shown that increased BAD expression enhances tumor growth, while knockdown of BAD expression by shRNA inhibits tumor growth.
Gene_expression (expression) of BAD associated with cancer and prostate cancer
16) Confidence 0.59 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.39 Pain Relevance 0
These experiments showed increased proliferation in several cell lines that transiently express BAD (Fig. 1C).
Gene_expression (express) of BAD
17) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.55 Pain Relevance 0
Thereby, it would not be surprising if cancer cells decrease BAD expression.
Gene_expression (expression) of BAD associated with cancer
18) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 1.29 Pain Relevance 0.08
To address the possible role of increased BAD expression, we examined proliferation of prostate cancer cells that overexpress BAD.
Gene_expression (expression) of BAD associated with prostate cancer
19) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.38 Pain Relevance 0.14
Analysis of the effect of BAD on prostate cancer xenografts has shown that increased BAD expression enhances tumor growth, while knockdown of BAD expression by shRNA inhibits tumor growth.
Gene_expression (expression) of BAD associated with cancer and prostate cancer
20) Confidence 0.59 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2704953 Disease Relevance 1.40 Pain Relevance 0

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