INT133857

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.59
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast)
Anatomy Link Frequency
skeletal muscles 1
Gast (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 77 96.24 Very High Very High Very High
cINOD 7 96.04 Very High Very High Very High
halothane 76 95.56 Very High Very High Very High
antagonist 15 87.20 High High
isoflurane 76 85.24 High High
potassium channel 12 70.56 Quite High
Kinase C 4 67.44 Quite High
Calcium channel 4 57.52 Quite High
chemokine 3 56.16 Quite High
analgesia 12 54.04 Quite High
Disease Link Frequency Relevance Heat
Infection 10 98.24 Very High Very High Very High
INFLAMMATION 69 95.48 Very High Very High Very High
Neurological Disease 3 95.00 High High
Injury 9 94.04 High High
Disease 108 93.76 High High
Anaerobic Bacterial Infections 1 90.44 High High
Hepatotoxicity 4 88.64 High High
Cancer 10 82.88 Quite High
Toxicity 4 72.80 Quite High
Unconsciousness 16 58.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bombesin/gastrin-releasing peptides (BN/GRP) were shown to bind selectively to cell surface receptors, stimulating the growth of various types of malignancies in murine and human models.
gastrin Binding (bind) of
1) Confidence 0.36 Published 2006 Journal Invest New Drugs Section Abstract Doc Link 16505950 Disease Relevance 0.24 Pain Relevance 0.08
We have previously shown that GAS bind to vimentin on injured skeletal muscles in vitro.
GAS Binding (bind) of in skeletal muscles
2) Confidence 0.34 Published 2008 Journal J. Infect. Dis. Section Abstract Doc Link 18939933 Disease Relevance 0.60 Pain Relevance 0.35
This method, however, yielded few useful results for gaseous GAs, because they associate with many proteins non-specifically (they bind to more than one sites).
GAs Binding (bind) of
3) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.08 Pain Relevance 0.14
In one direction is the development of coarse-grain simulations to study the interaction of GAs and membranes (Pickholz et al., 2005).
GAs Binding (interaction) of
4) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.03
Barbiturates were first synthesized in 1864, but their value as GAs was not recognized until 1903.
GAs Binding (recognized) of
5) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.25 Pain Relevance 0.14
Drawing on previous work by Jenkins et al. (2001) which showed that the binding site for haloalkane GAs in the GABAA receptor could only accommodate one molecule, they proposed that pressure reversal occurred when halothane aggregated, so fewer monomeric halothane was available to bind to the putative binding site.
GAs Binding (binding) of associated with halothane
6) Confidence 0.10 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.27
-responsive genes (i.e., those containing GAS (gamma activation sequence), IRF-E (interferon regulatory factor element), or ISRE (interferon-stimulated response element) binding sites) encode proteins implicated in immunoinflammatory processes [119, 120]; and hence, may be of particular relevance for neurological disorders such as PD.
GAS Binding (binding) of associated with neurological disease and disease
7) Confidence 0.06 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.41 Pain Relevance 0.08

General Comments

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