INT133858

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.65
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCS1L) mitochondrion organization (BCS1L)
Anatomy Link Frequency
fats 1
somas 1
tubules 1
kidney 1
BCS1L (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 6 82.16 Quite High
cINOD 3 80.24 Quite High
cocaine 4 80.00 Quite High
Dismenorea 1 47.68 Quite Low
Potency 3 46.00 Quite Low
cva 10 39.40 Quite Low
Pain 28 5.00 Very Low Very Low Very Low
withdrawal 25 5.00 Very Low Very Low Very Low
pruritus 12 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Premature Birth 410 100.00 Very High Very High Very High
Bacterial Vaginosis 24 99.70 Very High Very High Very High
Nephrotoxicity 6 99.14 Very High Very High Very High
Pre-term Labor 38 97.64 Very High Very High Very High
Acidosis 2 96.60 Very High Very High Very High
Ketosis 3 96.20 Very High Very High Very High
Hypocalcemia 4 95.84 Very High Very High Very High
Infection 28 94.24 High High
Body Weight 47 94.20 High High
Reprotox - General 3 16 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A major impediment in accepting progesterone as the magic bullet in the prevention of PTD is that its mechanism of action is less well understood than that of all the other prophylactic measures discussed in this review.
Negative_regulation (prevention) of PTD associated with premature birth
1) Confidence 0.51 Published 2006 Journal Am J Perinatol Section Abstract Doc Link 16506112 Disease Relevance 1.15 Pain Relevance 0
Moreover, there are limited evidence-based strategies available for prevention of PTD, reflecting our incomplete understanding of the nature of preterm labor.
Negative_regulation (prevention) of PTD associated with premature birth and pre-term labor
2) Confidence 0.51 Published 2006 Journal Am J Perinatol Section Abstract Doc Link 16506112 Disease Relevance 0.93 Pain Relevance 0
Several randomized clinical trials have assessed the role of bacterial vaginosis (BV) treatment in prevention of PTD.
Negative_regulation (prevention) of PTD associated with bacterial vaginosis and premature birth
3) Confidence 0.51 Published 2006 Journal Am J Perinatol Section Abstract Doc Link 16506112 Disease Relevance 1.42 Pain Relevance 0.08
The results of these studies reveal a beneficial effect in prolonging gestation for 48 hours, but without reduction in PTD rates.26–29
Negative_regulation (reduction) of PTD associated with premature birth
4) Confidence 0.42 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 1.04 Pain Relevance 0.03
We performed a retrospectively analysis of database of women enrolled for outpatient 17OHP-C prophylaxis for prevention of spontaneous PTB.110 The data were divided into three groups according to the number of PTD (1, 2, >2) and stratified to initiation of 17OHP-C at 16–20.9 weeks and 21–26.9 weeks.
Negative_regulation (number) of PTD associated with premature birth
5) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 0.77 Pain Relevance 0
Similarly, paternal inheritance has also been implicated, when studying a group of 128,239 women who had two consecutive births; Li et al70 observed that changing partners resulted in a 33% reduction in the risk of spontaneous PTD in women whose first pregnancy led to delivery before 34 weeks of gestation.
Negative_regulation (reduction) of PTD associated with premature birth
6) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 0.61 Pain Relevance 0
Attempts to understand rates of PTD in lower socioeconomic groups have not yet yielded benefit in terms of providing clues to the cause of PTB in general.30 Furthermore, attempts at intervention by improvement of social support mechanisms in this population have neither resulted in a decrease in the rates of PTD nor in improvement in outcome by any perinatal measures.34,35
Neg (nor) Negative_regulation (decrease) of PTD associated with premature birth
7) Confidence 0.31 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 1.01 Pain Relevance 0.04
Excessive loss of BCS and excess protein content of the ration can reduce CR while supplemental fats that attenuate the production of F2alpha can improve CR.
Negative_regulation (loss) of BCS in fats
8) Confidence 0.12 Published 2006 Journal Anim. Reprod. Sci. Section Abstract Doc Link 16996705 Disease Relevance 0.71 Pain Relevance 0
We quantified the number of electroporated ON BCs in which the WT TRPM1 protein was localized more in the dendritic tips than somas.
Negative_regulation (number) of BCs in somas
9) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0 Pain Relevance 0
Induction of VTG in the young roach exposed to effluent was associated with increased numbers of glomeruli, increases in size of kidney tubules, and higher numbers of BCs and DNs (reflecting the increased demand for filtration of VTG for its removal from the circulation).
Negative_regulation (numbers) of BCs in tubules
10) Confidence 0.04 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1874182 Disease Relevance 0 Pain Relevance 0
Field evidence indicates that wild fish sampled from sites of known contamination have higher numbers of BCs and DNs than do fish of the same species taken from less contaminated reference sites (Cormier et al. 1995).
Negative_regulation (numbers) of BCs
11) Confidence 0.04 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1874182 Disease Relevance 0.16 Pain Relevance 0
BCs and DNs have been proposed as useful biomarkers for assessing nephrotoxicity (Cormier et al. 1995), and in this study, numbers of glomeruli, DNs, and BCs were counted over one field of view of a kidney cross-section.
Negative_regulation (numbers) of BCs in kidney associated with nephrotoxicity
12) Confidence 0.04 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1874182 Disease Relevance 0.22 Pain Relevance 0.04
Biweekly BCS decreased in C ewes from diet initiation to breeding due to a statistically significant (P < 0.05), yet slight decrease in BCS of approximately 0.5 score unit which occurred in the first several weeks of the study, and maintained a relatively constant BCS thereafter.
Negative_regulation (decrease) of BCS
13) Confidence 0.04 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2911461 Disease Relevance 0.64 Pain Relevance 0

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