INT133863

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.53
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
cleavage 18
plaques 2
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 8 99.92 Very High Very High Very High
Inflammation 211 99.40 Very High Very High Very High
metalloproteinase 1 92.60 High High
cytokine 100 89.88 High High
chemokine 15 89.36 High High
Inflammatory mediators 23 87.52 High High
Neurotransmitter 7 85.68 High High
Hippocampus 70 84.36 Quite High
Central nervous system 55 78.36 Quite High
Eae 6 65.24 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 292 100.00 Very High Very High Very High
Disease 646 99.52 Very High Very High Very High
INFLAMMATION 287 99.40 Very High Very High Very High
Amyloid Plaque 102 98.32 Very High Very High Very High
Disease Progression 8 95.16 Very High Very High Very High
Targeted Disruption 300 85.60 High High
Toxicity 14 82.60 Quite High
Cognitive Disorder 80 74.96 Quite High
Immunization 7 70.48 Quite High
Frailty 17 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 canstimulate the synthesis and cleavage of glial APP, caution has to be exerted when extrapolating this conclusion to an in vivo context: the mice used in the present study produce TGF-?
Positive_regulation (exerted) of Protein_catabolism (cleavage) of APP in cleavage
1) Confidence 0.59 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.06 Pain Relevance 0
Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase.
Positive_regulation (derived) of Protein_catabolism (cleaved) of amyloid precursor protein associated with alzheimer's dementia and abeta
2) Confidence 0.50 Published 2005 Journal Drugs Aging Section Abstract Doc Link 16506440 Disease Relevance 0.88 Pain Relevance 0.18
Abeta is derived from amyloid precursor protein (APP), which is cleaved by several different proteases: alpha-, beta- and gamma-secretase.
Positive_regulation (derived) of Protein_catabolism (cleaved) of APP associated with alzheimer's dementia and abeta
3) Confidence 0.50 Published 2005 Journal Drugs Aging Section Abstract Doc Link 16506440 Disease Relevance 0.88 Pain Relevance 0.18
-secretase cleavage by an elusive mechanism that modulates the proteolysis of APP to selectively enhance the generation of highly amyloidogenic A?
Positive_regulation (enhance) of Protein_catabolism (proteolysis) of APP in cleavage
4) Confidence 0.46 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.65 Pain Relevance 0
The Swedish mutation enhances the cleavage of APP by BACE1.
Positive_regulation (enhances) of Protein_catabolism (cleavage) of APP in cleavage
5) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.35 Pain Relevance 0
The Swedish mutation enhances the cleavage of APP by BACE1.
Positive_regulation (enhances) of Protein_catabolism (cleavage) of APP in cleavage
6) Confidence 0.44 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.23 Pain Relevance 0
Additionally, inflammatory molecule signaling may cause increased cleavage of APP by the ?
Positive_regulation (increased) of Protein_catabolism (cleavage) of APP in cleavage associated with inflammation
7) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.74 Pain Relevance 0.38
1 canstimulate the synthesis and cleavage of glial APP, caution has to be exerted when extrapolating this conclusion to an in vivo context: the mice used in the present study produce TGF-?
Positive_regulation (canstimulate) of Protein_catabolism (cleavage) of APP in cleavage
8) Confidence 0.42 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC500868 Disease Relevance 0.06 Pain Relevance 0
The wild-type human ADAM10 gene, in a mouse line carrying hAPP with the London mutation, increased the alpha-cleavage of APP, reduced the concentration of A?
Positive_regulation (increased) of Protein_catabolism (cleavage) of APP in cleavage
9) Confidence 0.41 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.69 Pain Relevance 0.08
In contrast, the amyloidogenic cleavage of APP is initiated by ?
Positive_regulation (initiated) of Protein_catabolism (cleavage) of APP in cleavage
10) Confidence 0.37 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.40 Pain Relevance 0.08
-secretase TACE, thus increasing non-amyloidogenic cleavage of APP and decreasing A?
Positive_regulation (increasing) of Protein_catabolism (cleavage) of APP in cleavage
11) Confidence 0.35 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2784760 Disease Relevance 1.02 Pain Relevance 0.46
It seems to be proved that these cells secrete beta-myloid protein and are responsible for the alternative pathway cleavage of beta-amyloid precursor protein to yield amyloidogenesis fragments in AD senile plaques (Dziedzic 2006).
Positive_regulation (responsible) of Protein_catabolism (cleavage) of beta-amyloid precursor protein in plaques associated with alzheimer's dementia, disease and amyloid plaque
12) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 1.57 Pain Relevance 0.16

General Comments

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