INT133874

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.82
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
fibroblast 2
mast cells 2
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 3 90.24 High High
cINOD 2 85.04 High High
Inflammation 11 84.56 Quite High
Osteoarthritis 22 62.28 Quite High
fibrosis 32 55.92 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Pain 8 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 86 99.62 Very High Very High Very High
Stress 22 98.52 Very High Very High Very High
Apoptosis 26 96.00 Very High Very High Very High
Hypoxia 62 94.72 High High
Stomach Cancer 3 93.60 High High
Heterotopic Ossification 54 92.64 High High
INFLAMMATION 13 84.56 Quite High
Cancer 5 80.56 Quite High
Metaplasia 16 75.00 Quite High
Osteoarthritis 22 62.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of both vascular endothelial growth factor (VEGF) and FGF-1 was suppressed.
Negative_regulation (suppressed) of Gene_expression (Expression) of FGF-1
1) Confidence 0.24 Published 2005 Journal Biomed. Pharmacother. Section Abstract Doc Link 16507395 Disease Relevance 0.61 Pain Relevance 0.30
The fibrotic tissue also contained nitrosylated proteins concordant with elevated numbers of chymase and FGF producing mast cells, indicative of oxidative stress and increased fibroproliferative factors driving cell survival and proliferation.
Negative_regulation (numbers) of Gene_expression (producing) of FGF in mast cells associated with stress and fibrosis
2) Confidence 0.16 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.14 Pain Relevance 0.06
Within the fibrotic regions, elevated numbers of chymase/fibroblast growth factor (FGF)-expressing mast cells were observed.
Negative_regulation (numbers) of Gene_expression (expressing) of FGF in fibroblast associated with fibrosis
3) Confidence 0.16 Published 2010 Journal Fibrogenesis Tissue Repair Section Abstract Doc Link PMC2940819 Disease Relevance 1.07 Pain Relevance 0

General Comments

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