INT133875

Context Info Confidence 0.58 First Reported 2004 Last Reported 2011 Negated 1 Speculated 0 Reported most in Body Documents 26 Total Number 30 Disease Relevance 17.10 Pain Relevance 1.48

transferase activity, transferring glycosyl groups (POMT1) endoplasmic reticulum (POMT1) extracellular matrix organization (POMT1) carbohydrate metabolic process (POMT1)

Anatomy Link Frequency plasma 1 muscle 1 brain 1 Lung 1 POMT1 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 299 98.52 tolerance 90 97.00 Mechanotransduction 1 91.72 Inflammation 61 88.24 Pain 57 80.84 Angina 9 80.40 cytokine 474 80.20 behavioral therapy 2 48.80 corticosteroid 11 48.52 Acupuncture 2 41.52

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 131 100.00 Radiation Pneumonitis 504 99.88 Handedness 145 99.80 Brain Tumor 4 98.46 Rhabdomyosarcoma 112 98.44 Infection 47 97.90 Impaired Glucose Tolerance 145 97.32 Apoptosis 82 96.96 Toxicity 145 96.80 Cancer 1040 96.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, in a longitudinal study of patients with brain tumors who underwent RT [10], the two symptom clusters that were identified at the beginning of RT did not change over the course of RT.

Gene_expression (beginning) of RT in brain associated with brain tumor

1) Confidence 0.58 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2762051 Disease Relevance 0.34 Pain Relevance 0

While this approach resulted in different numbers of symptoms being included in each EFA, it took into consideration the fact that as patients progress through RT, the occurrence and severity of specific symptoms may change over time.

Gene_expression (progress) of RT

2) Confidence 0.58 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2762051 Disease Relevance 0 Pain Relevance 0

In one patient, misalignment occurred because the positioning was not accurate due to the fact that the RT position could not be reproduced (Fig. 1).

Gene_expression (position) of RT

3) Confidence 0.18 Published 2007 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2275773 Disease Relevance 0.71 Pain Relevance 0.05

In our series, repositioning of the patient during SPECT scan in RT position was standard procedure, but due to the limitations in fixation, not optimal.

Gene_expression (position) of RT

4) Confidence 0.15 Published 2007 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2275773 Disease Relevance 0.87 Pain Relevance 0.04

That is, it was hypothesized that these participants would show a different RT profile for laterality judgments of their affected versus their non-affected hand, but this was not evidenced by the data.

Gene_expression (profile) of RT associated with handedness

5) Confidence 0.12 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0.58 Pain Relevance 0.26

Thus, the RT profiles of imagined hand rotations were subject to the same biomechanical constraints experienced for overt movement.

Gene_expression (profiles) of RT

6) Confidence 0.12 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0.38 Pain Relevance 0.13

However, we now only included RT values of the Set-1 stimuli in all sets.

Gene_expression (values) of RT

7) Confidence 0.12 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0 Pain Relevance 0.04

The embodied nature of MI in a hand laterality judgment task was further evidenced by showing that RT profiles change as a consequence of changing the participant’s posture (Parsons 1994; Sirigu and Duhamel 2001; de Lange et al. 2006; Helmich et al. 2007; Ionta et al. 2007; Ionta and Blanke 2009).

Gene_expression (profiles) of RT associated with handedness and imagery

8) Confidence 0.12 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0.43 Pain Relevance 0.36

Overall, RTs increased significantly with increasing angle of rotation for all three sets, see Fig. 2.Fig. 2Reaction times for all three sets, mirrored at 180° (i.e., 60° represents average RT for 60° and 300° rotated hand stimuli).

Gene_expression (average) of RT

9) Confidence 0.12 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0 Pain Relevance 0

Other options are the use of modulated RT (IMRT) and proton therapy [112, 113].

Gene_expression (use) of RT

10) Confidence 0.12 Published 2008 Journal Pediatr Radiol Section Body Doc Link PMC2367394 Disease Relevance 0.91 Pain Relevance 0.03

To this end, reverse transcription (RT) polymerase chain reaction (PCR) was used to quantify expression levels of 5?

Gene_expression (expression) of RT

11) Confidence 0.11 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.59 Pain Relevance 0

The following NRTI inhibitors of HIV-1 RT were tested in our XMRV replication assays: ZDV, 3?

Gene_expression (tested) of RT associated with acquired immune deficiency syndrome or hiv infection

12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848589 Disease Relevance 0.36 Pain Relevance 0

These drugs are ineffective against MoMLV, because in MoMLV RT, V is the natural residue in this motif in place of M.

Gene_expression (residue) of RT

13) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848589 Disease Relevance 0.32 Pain Relevance 0

To test the priming ability of ADVAX, two clinical trials are now being conducted in the United Kingdom and in India, respectively, where 2 or 3 doses of 4 mg of ADVAX, either administered by Biojector ® 2000 or regular intramuscular needle injection, are given as prime followed by a recombinant multigenic MVA expressing HIV-1 Clade C env, gag, RT, rev, tat and nef genes [23].

Gene_expression (expressing) of RT associated with acquired immune deficiency syndrome or hiv infection

14) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799527 Disease Relevance 0.38 Pain Relevance 0

We evaluated COX-2 expression with reverse transcriptase (RT)-polymerase chain reaction (PCR) and immunoblotting.

Gene_expression (expression) of RT

15) Confidence 0.07 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16507712 Disease Relevance 0.40 Pain Relevance 0.17

1 end-RT/TGF-?

Gene_expression (/) of RT

16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 0.82 Pain Relevance 0

1 peak value during RT (IL-6 peak-RT/IL-6 pre-RT; TGF-?

Gene_expression (peak) of RT

17) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 0.86 Pain Relevance 0

The ratios (IL-6 end-RT/IL-6 pre-RT; TGF-?

Gene_expression (pre) of RT

18) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 0.83 Pain Relevance 0

Lung function tests (forced expiratory volume; vital capacity; diffusion capacity, etc.) were accomplished before RT, and at every follow-up examination.

Gene_expression (accomplished) of RT in Lung

19) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 1.42 Pain Relevance 0.15

1 peak value during RT (IL-6 peak-RT/IL-6 pre-RT; TGF-?

Gene_expression (pre) of RT

20) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 0.86 Pain Relevance 0

General Comments

This test has worked.