INT133876

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2011
Negated 2
Speculated 5
Reported most in Body
Documents 141
Total Number 146
Disease Relevance 75.55
Pain Relevance 27.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) signal transduction (Ros1)
plasma membrane (Ros1) kinase activity (Ros1)
Anatomy Link Frequency
respiratory 20
neurons 19
heart 8
leucocytes 8
astrocytes 7
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 449 100.00 Very High Very High Very High
qutenza 1225 99.98 Very High Very High Very High
Glutamate 68 99.98 Very High Very High Very High
Kinase C 862 99.96 Very High Very High Very High
ischemia 380 99.92 Very High Very High Very High
dorsal root ganglion 1002 99.84 Very High Very High Very High
potassium channel 1597 99.82 Very High Very High Very High
chemokine 133 99.72 Very High Very High Very High
Inflammation 1720 99.68 Very High Very High Very High
tolerance 178 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 2701 100.00 Very High Very High Very High
Neutrophil Disorders 25 100.00 Very High Very High Very High
Stress 1310 99.98 Very High Very High Very High
Cv Unclassified Under Development 1716 99.92 Very High Very High Very High
Ganglion Cysts 1044 99.84 Very High Very High Very High
Fatty Liver 678 99.84 Very High Very High Very High
Alzheimer's Dementia 280 99.84 Very High Very High Very High
Injury 478 99.82 Very High Very High Very High
Disease 2248 99.80 Very High Very High Very High
Atherosclerosis 156 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant increases in ROS production do not occur in the present study until 30 minutes since ROS levels in cells are tightly regulated.
Positive_regulation (increases) of Gene_expression (production) of ROS
1) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.30 Pain Relevance 0.53
Capsaicin increases ROS production in DRG neurons of wild type mice
Positive_regulation (increases) of Gene_expression (production) of ROS in neurons associated with dorsal root ganglion and qutenza
2) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.37 Pain Relevance 0.72
The data indicate that ROS production is increased by challenging neurons with capsaicin/resiniferatoxin.
Positive_regulation (increased) of Gene_expression (production) of ROS in neurons associated with qutenza
3) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.19 Pain Relevance 0.46
The results are supported in experiments done on synoviocyte cultures showing that ROS production was induced by calcium influxes elicited by TRPV1 activation [40].
Positive_regulation (induced) of Gene_expression (production) of ROS
4) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.11 Pain Relevance 0.47
Although there was a slow, steady increase of ROS production in all neurons in normal physiological experimental solution due to spontaneous oxidation of the dye over time, ROS production was significantly increased in cultured DRG neurons after bath application of capsaicin (1 ?
Positive_regulation (increase) of Gene_expression (production) of ROS in neurons associated with dorsal root ganglion and qutenza
5) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.42 Pain Relevance 0.71
The results from TRPV1 deficient mice show no increase in ROS production after capsaicin stimulation.
Neg (no) Positive_regulation (increase) of Gene_expression (production) of ROS associated with qutenza
6) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.18 Pain Relevance 0.48
Although there was a slow, steady increase of ROS production in all neurons in normal physiological experimental solution due to spontaneous oxidation of the dye over time, ROS production was significantly increased in cultured DRG neurons after bath application of capsaicin (1 ?
Positive_regulation (increased) of Gene_expression (production) of ROS in neurons associated with dorsal root ganglion and qutenza
7) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.35 Pain Relevance 0.62
ROS are not only endpoint products of TRPV1 activation but also signaling pathway elements.
Positive_regulation (activation) of Gene_expression (products) of ROS
8) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.86 Pain Relevance 0.74
CONCLUSIONS: CAP mediates cell death in T24 cells through calcium entry-dependent ROS production and mitochondrial depolarization, and it may have a role in the management of bladder cancer.


Positive_regulation (dependent) of Gene_expression (production) of ROS in bladder
9) Confidence 0.23 Published 2010 Journal Urology Section Body Doc Link 19592070 Disease Relevance 0 Pain Relevance 0
Although there was a slow, steady increase of ROS production in all neurons in normal physiological experimental solution due to spontaneous oxidation of the dye over time, ROS production was significantly increased in cultured DRG neurons after bath application of capsaicin (1 ?
Positive_regulation (over) of Gene_expression (production) of ROS in neurons associated with dorsal root ganglion and qutenza
10) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.36 Pain Relevance 0.62
Although there was a slow, steady increase of ROS production in all neurons in normal physiological experimental solution due to spontaneous oxidation of the dye over time, ROS production was significantly increased in cultured DRG neurons after bath application of capsaicin (1 ?
Positive_regulation (over) of Gene_expression (production) of ROS in neurons associated with dorsal root ganglion and qutenza
11) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.42 Pain Relevance 0.73
The DCF accumulation indicates that ROS production is increasing.
Positive_regulation (increasing) of Gene_expression (production) of ROS
12) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.47 Pain Relevance 0.74
TRPV1 activation induces increases in ROS production
Positive_regulation (increases) of Gene_expression (production) of ROS
13) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.36 Pain Relevance 0.32
The PBN (2 mM) added 90 min prior to start of recording abolished ROS production induced by capsaicin (1 ?
Positive_regulation (induced) of Gene_expression (production) of ROS associated with qutenza
14) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.08 Pain Relevance 0.54
However, the mechanism of generating calcium influx in response to ROS production increase is still unclear.
Positive_regulation (increase) of Gene_expression (production) of ROS
15) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.28 Pain Relevance 0.47
Although there was a slow, steady increase of ROS production in all neurons in normal physiological experimental solution due to spontaneous oxidation of the dye over time, ROS production was significantly increased in cultured DRG neurons after bath application of capsaicin (1 ?
Positive_regulation (increase) of Gene_expression (production) of ROS in neurons associated with dorsal root ganglion and qutenza
16) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.42 Pain Relevance 0.71
Although there was a slow, steady increase of ROS production in all neurons in normal physiological experimental solution due to spontaneous oxidation of the dye over time, ROS production was significantly increased in cultured DRG neurons after bath application of capsaicin (1 ?
Positive_regulation (increased) of Gene_expression (production) of ROS in neurons associated with dorsal root ganglion and qutenza
17) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.35 Pain Relevance 0.62
PBN blocks TRPV1 activated increases in ROS production in DRG neurons of wild type mice
Positive_regulation (increases) of Gene_expression (production) of ROS in neurons associated with dorsal root ganglion
18) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.57 Pain Relevance 0.95
MLT (0.1, 1, 10 or 100 microM) dose-dependently attenuated the increase in both production of ROS and lipid peroxidation by AA.
Positive_regulation (increase) of Gene_expression (production) of ROS associated with paracetamol
19) Confidence 0.22 Published 2006 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16508148 Disease Relevance 0.48 Pain Relevance 1.21
M) and resiniferatoxin (200 nM) induced increases in ROS production.
Positive_regulation (increases) of Gene_expression (production) of ROS
20) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.42 Pain Relevance 0.84

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