INT133885

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 1.27
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN2A)
Anatomy Link Frequency
blood 2
SCN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 6 100.00 Very High Very High Very High
sodium channel 6 98.08 Very High Very High Very High
local anesthetic 8 97.14 Very High Very High Very High
Paroxysmal extreme pain disorder 1 91.20 High High
potassium channel 2 88.84 High High
gABA 3 75.68 Quite High
Pain 7 50.00 Quite Low
depression 1 50.00 Quite Low
Calcium channel 11 5.00 Very Low Very Low Very Low
amygdala 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epilepsy 3 99.28 Very High Very High Very High
Channelopathies 2 98.50 Very High Very High Very High
Convulsion 1 96.40 Very High Very High Very High
Stress 23 95.96 Very High Very High Very High
Syndrome 3 94.72 High High
Myoclonic Epilepsies 1 94.04 High High
Somatoform Disorder 1 90.44 High High
Diabetes Mellitus 2 64.12 Quite High
Mental Disorders 1 62.08 Quite High
Disease 7 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In multivariable analyses, pain was not associated with HbA(1c) (P = 0.304) but was strongly associated with worse MCS-12 (P < 0.001), PCS-12 (P < 0.001) and depression (P < 0.001).
HbA Binding (associated) of
1) Confidence 0.47 Published 2010 Journal Diabet. Med. Section Body Doc Link 20536955 Disease Relevance 0.19 Pain Relevance 0
In accordance with experimental mutagenesis studies, computational docking of tetrodotoxin and tetracaine provided (1) a description of site 1 toxin and local anesthetic binding sites in voltage-gated sodium channels. (2) A rationale for site 1 toxin-sensitivity versus -insensitivity in atomic detail involving interactions of the Na(v)1.2 residues F385-I and W943-II. (3) A working hypothesis of interactions between Na(v)1.8 in different conformational states and the local anesthetic tetracaine.
Na(v)1.2 Binding (interactions) of associated with tetrodotoxin, sodium channel and local anesthetic
2) Confidence 0.36 Published 2006 Journal J Mol Model Section Abstract Doc Link 16508760 Disease Relevance 0 Pain Relevance 0.75
The resulting draft models were used to study the differences of tetrodotoxin binding to the tetrodotoxin-sensitive Na(v)1.2 (EC50: 0.012 microM) and -insensitive Na(v)1.8 (EC50: 60 microM) isoforms, respectively.
Na(v)1.2 Binding (binding) of associated with tetrodotoxin
3) Confidence 0.35 Published 2006 Journal J Mol Model Section Abstract Doc Link 16508760 Disease Relevance 0 Pain Relevance 0.66
These channelopathies include genes encoding voltage-gated channels specific for sodium (SCN1A, SCN2A, SCN1B, SCN9A) and potassium (KCNQ2, KCNQ3) which account for a variety of epilepsy phenotypes ranging from mild, such as Benign familial neonatal seizures (BFNS) to severe, such as Dravet syndrome (severe myoclonic epilepsy of infancy, SMEI) and the rare and unusual syndrome paroxysmal extreme pain disorder (PEPD).
SCN2A Binding (account) of associated with somatoform disorder, epilepsy, convulsion, syndrome, myoclonic epilepsies, paroxysmal extreme pain disorder and channelopathies
4) Confidence 0.33 Published 2006 Journal Early Hum. Dev. Section Abstract Doc Link 17049761 Disease Relevance 0.87 Pain Relevance 0.13
Nuclear protein extracts containing REST protein were incubated with a radiolabelled promoter fragment containing the rat SCN2A2 RE1 (40), as well as unlabelled competitor oligonucleotides representing test sequences.
SCN2A2 Binding (containing) of
5) Confidence 0.27 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1557810 Disease Relevance 0.06 Pain Relevance 0
The power to detect a dominance effect between the two parental lines (d = a) were 0.21, 0.47, 0.40, and 0.19 for HBA, HBB, HBE and HEBP1, respectively.
HBA Binding (0.19) of
6) Confidence 0.15 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0.06 Pain Relevance 0
To examine if an increased blood perfusion could be the main driver of the observed mRNA differences between S and NS foxes, we assumed that the average HBA and HBB levels (HB) may reflect the maximum effect of blood perfusion.
HBA Binding (average) of in blood
7) Confidence 0.15 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0 Pain Relevance 0
Thus to evaluate the potential effect of blood perfusion on HBE and HEBP1 expression levels, we assumed that the average HBA and HBB levels (HB) could represent the maximum effect of blood perfusion caused by e.g. a systemic stress response.
HBA Binding (average) of in blood associated with stress
8) Confidence 0.15 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1858698 Disease Relevance 0.10 Pain Relevance 0
However, the probe HbA-26, specific for the normal genotype at c26, recognized the all samples with OD values above 2.0 (data not shown).
HbA Binding (recognized) of
9) Confidence 0.05 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0 Pain Relevance 0

General Comments

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