INT133889

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Context Info
Confidence 0.76
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 78
Total Number 80
Disease Relevance 48.05
Pain Relevance 6.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts1) extracellular region (Adamts1) proteinaceous extracellular matrix (Adamts1)
Anatomy Link Frequency
blood vessel 8
tendon 6
cartilage 5
vessels 3
monocytes 2
Adamts1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 592 100.00 Very High Very High Very High
Osteoarthritis 283 99.96 Very High Very High Very High
cytokine 125 99.30 Very High Very High Very High
Hippocampus 42 98.08 Very High Very High Very High
Deafferentation 35 98.00 Very High Very High Very High
Pain 121 97.76 Very High Very High Very High
Mechanotransduction 5 97.28 Very High Very High Very High
Central nervous system 70 94.72 High High
Arthritis 198 92.64 High High
Inflammation 126 92.12 High High
Disease Link Frequency Relevance Heat
Vascular Tissue Neoplasms 39 100.00 Very High Very High Very High
Osteoarthritis 283 99.96 Very High Very High Very High
Prostate Cancer 975 99.92 Very High Very High Very High
Cancer 4353 99.76 Very High Very High Very High
Congenital Anomalies 97 99.58 Very High Very High Very High
Malignant Neoplastic Disease 118 98.92 Very High Very High Very High
Targeted Disruption 231 98.62 Very High Very High Very High
Disorder Of Lipid Metabolism 274 98.38 Very High Very High Very High
Metastasis 235 98.26 Very High Very High Very High
Growth Problems 27 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also in the human prostate, ADAMTS1 was downregulated in tumor tissue compared to benign tissue and decreased expression of ADAMTS1 was associated with increased angiogenesis and metastasis in androgen-independent tumors [19].
Gene_expression (expression) of ADAMTS1 associated with cancer and metastasis
1) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.24 Pain Relevance 0
However, modified ADAMTS1 expression did not affect the cleavage of TSP1 in LNCaP or LNCaP-19 tumors.
Gene_expression (expression) of ADAMTS1 in cleavage associated with cancer
2) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.97 Pain Relevance 0
Three weeks later, stably transfected clones were isolated, expanded and screened for ADAMTS1 expression by real-time RT-PCR and western blotting.
Gene_expression (expression) of ADAMTS1
3) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.16 Pain Relevance 0
That increased expression of ADAMTS1 is associated with a less malignant phenotype of androgen-independent prostate tumors has also been shown in PC-3 tumors [31].
Gene_expression (expression) of ADAMTS1 in PC-3 associated with malignant neoplastic disease, cancer and prostate cancer
4) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.49 Pain Relevance 0
This is in accordance with our study, where decreased expression of ADAMTS1 was associated with increased TSP1 and a switch from large vessels into small vessels, while overexpression of ADAMTS1 resulted in loss of TSP1 and a switch back to larger vessels.
Gene_expression (expression) of ADAMTS1 in vessels
5) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.85 Pain Relevance 0
Instead, we found that ADAMTS1 expression was inversely related to the total levels of TSP1 in the tumor xenografts.
Gene_expression (expression) of ADAMTS1 associated with cancer
6) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.97 Pain Relevance 0
The blood vessel morphology was similarly affected by ADAMTS1 expression in LNCaP-19 tumors.
Gene_expression (expression) of ADAMTS1 in blood vessel associated with cancer
7) Confidence 0.76 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.14 Pain Relevance 0
KK established the ADAMTS1 expression vector system.
Gene_expression (expression) of ADAMTS1
8) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.51 Pain Relevance 0
SureSilencing shRNA plasmids for human ADAMTS1 with neomycin (#KH01149N, SABiosciences, Frederick, MD) were used to downregulate the expression of ADAMTS1 by RNA interference in LNCaP cells.
Gene_expression (expression) of ADAMTS1
9) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.49 Pain Relevance 0
However, modified expression of ADAMTS1 did not influence the degree of pericyte coverage, indicating that altered vessel stabilization by pericytes is not involved in the altered blood vessel morphology observed.
Gene_expression (expression) of ADAMTS1 in blood vessel
10) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.79 Pain Relevance 0
In this study, re-expression of ADAMTS1 in LNCaP-19 greatly delayed tumor establishment, indicating that ADAMTS1 actually might function as a tumor suppressor of androgen-independent prostate tumors.
Gene_expression (expression) of ADAMTS1 associated with cancer and prostate cancer
11) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.41 Pain Relevance 0
ADAMTS1 has been reported to efficiently inhibit tumor growth and metastasis in different experimental cancer models by blocking angiogenesis [3-5], and decreased expression of ADAMTS1 has been reported in human malignancies [11-13].
Gene_expression (expression) of ADAMTS1 associated with cancer and metastasis
12) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.11 Pain Relevance 0.10
This is in accordance with our study, where decreased expression of ADAMTS1 was associated with increased TSP1 and a switch from large vessels into small vessels, while overexpression of ADAMTS1 resulted in loss of TSP1 and a switch back to larger vessels.
Gene_expression (overexpression) of ADAMTS1 in vessels
13) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.75 Pain Relevance 0
Modified expression of ADAMTS1 induced a clear difference in blood vessel morphology.
Gene_expression (expression) of ADAMTS1 in blood vessel
14) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.44 Pain Relevance 0
Modified expression of ADAMTS1 in LNCaP and LNCaP-19 cells
Gene_expression (expression) of ADAMTS1
15) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.34 Pain Relevance 0
Real-time RT-PCR and western blotting analysis revealed significantly decreased mRNA and protein levels of ADAMTS1 in LA- tumors compared to LC tumors (Figure 1A, B, C) and an obvious increase in ADAMTS1 expression in L19A + tumors compared to L19C tumors (Figure 1D, E, F).
Gene_expression (expression) of ADAMTS1 associated with cancer
16) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.01 Pain Relevance 0
LNCaP-19 cells (L19 wt), originally expressing low amounts of ADAMTS1, were stably transfected with an expression vector containing the full-length ADAMTS1 (L19A+) or control vector (L19C).
Gene_expression (expressing) of ADAMTS1
17) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.46 Pain Relevance 0
Interestingly, we found that modified expression of ADAMTS1 markedly altered the blood vessel morphology in these tumor xenografts, while the number of blood vessels was unaffected.
Gene_expression (expression) of ADAMTS1 in blood vessels associated with cancer
18) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.03 Pain Relevance 0
LNCaP cells (L wt) that originally express significant amounts of ADAMTS1 were stably transfected with shRNA plasmids against ADAMTS1 (LA-) or control vector (LC).
Gene_expression (express) of ADAMTS1
19) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.44 Pain Relevance 0
Since TSP1 is a potent angiogenesis inhibitor, this may explain why the MVD in the tumor xenografts was not affected by altered levels of ADAMTS1.
Gene_expression (levels) of ADAMTS1 associated with cancer
20) Confidence 0.66 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.90 Pain Relevance 0

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