INT133905

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 10.20
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ncam1) cell adhesion (Ncam1) plasma membrane (Ncam1)
Anatomy Link Frequency
neural 5
neurons 4
muscle 2
natural killer cell 2
smooth muscle 1
Ncam1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 2 99.70 Very High Very High Very High
Dorsal horn 6 99.68 Very High Very High Very High
Morphine 12 99.50 Very High Very High Very High
Glutamate receptor 11 99.28 Very High Very High Very High
Spinal cord 18 98.68 Very High Very High Very High
cytokine 16 98.28 Very High Very High Very High
Sciatic nerve 24 98.24 Very High Very High Very High
fluoxetine 43 97.58 Very High Very High Very High
Peripheral nervous system 9 97.04 Very High Very High Very High
tolerance 3 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 127 100.00 Very High Very High Very High
Diabetes Mellitus 6 99.42 Very High Very High Very High
Cancer 75 97.92 Very High Very High Very High
Muscle Disease 116 97.20 Very High Very High Very High
Disease 45 96.32 Very High Very High Very High
Nervous System Injury 5 95.16 Very High Very High Very High
Neurodegenerative Disease 74 94.96 High High
Cardiovascular Disease 80 94.84 High High
Rheumatoid Arthritis 155 93.64 High High
Fasciculation 39 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine treatment increases the expression of the neural cell adhesion molecule in the dorsal horn of the mouse spinal cord.
Gene_expression (expression) of neural cell adhesion molecule in dorsal horn associated with dorsal horn, adhesions, spinal cord and morphine
1) Confidence 0.78 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16510246 Disease Relevance 0.26 Pain Relevance 1.20
All antigens used here including c-Kit, CD34, vimentin, smooth muscle actin (SMA), desmin, S100 protein, synaptophysin, CD56 and Ki67 (MIB-1) were summarized in Table 2.
Gene_expression (used) of CD56 in smooth muscle
2) Confidence 0.65 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 0.83 Pain Relevance 0.06
These findings support the idea that repeated stimulation of mu-opioid receptors increases the expression of neural cell adhesion molecule and metabotropic glutamate receptor 5.
Gene_expression (expression) of neural cell adhesion molecule in neural associated with glutamate receptor, mu opioid receptor and adhesions
3) Confidence 0.60 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16510246 Disease Relevance 0.26 Pain Relevance 1.20
Rathjen, Max-Delbrück-Centrum, Berlin, Germany), PSA-NCAM (mouse IgM, 1.1000; AbCys, Paris, France), L1 (rabbit polyclonal, 1?
Gene_expression (rabbit) of NCAM in Centrum
4) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0.03
Deficiency of NCAM, and other adhesion molecules such as L1, often results in axonal defasciculation [9], [50], [51]. ncam-deficient mice, for instance, show defasciculation of mossy fibers in the hippocampus [50] and pathfinding errors and reduced fasciculation of the corticospinal tract [52].
Gene_expression (Deficiency) of NCAM in mossy fibers associated with fasciculation, hippocampus and adhesions
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.42 Pain Relevance 0.14
To our knowledge, PC is the second highly-sialylated adhesion glycoprotein expressed in neurons, in addition to NCAM.
Gene_expression (expressed) of NCAM in neurons associated with adhesions
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.18 Pain Relevance 0
Histologic features were observed and immunohistochemical detection of cytokeratin (CK), epithelial membrane antigen (EMA), neuron specific enolase (NSE), synaptophysin (Syn), chromogranin A (CgA), neuronal cell adhesion molecules (CD56), thyroid transcriptional factor-1 (TTF-1) and S100 protein (S100) was performed.


Gene_expression (detection) of CD56 in neuron associated with adhesions
7) Confidence 0.43 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1829164 Disease Relevance 0.99 Pain Relevance 0
Recently, it was reported that a transient increase in the expression of NCAM occurs in neurons after transection of the sciatic nerve, suggesting that NCAM is also involved in regeneration of the peripheral nervous system [20].
Gene_expression (expression) of NCAM in sciatic nerve associated with peripheral nervous system and sciatic nerve
8) Confidence 0.41 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.36 Pain Relevance 0.10
In the olfactory epithelium, there is one report that the level of NCAM expression is elevated transiently after resection of the olfactory bulb [29].
Gene_expression (expression) of NCAM in olfactory bulb
9) Confidence 0.41 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.48 Pain Relevance 0.10
NCAM is expressed abundantly throughout the nervous system.
Gene_expression (expressed) of NCAM in nervous system
10) Confidence 0.41 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.48 Pain Relevance 0.06
In support of this is the observation that overexpression of NCAM in mouse muscle leads to sprouting both within and away from the NMJs (Walsh et al. 2000).
Gene_expression (overexpression) of NCAM in muscle
11) Confidence 0.40 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.18 Pain Relevance 0
(Park et al 1997), cytotoxic capabilities, and expression of natural killer cell markers including CD56 (Michel et al 2007) and killer immunoglobulin-like receptors.
Gene_expression (expression) of CD56 in natural killer cell
12) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515420 Disease Relevance 1.13 Pain Relevance 0.25
Alpha-dystroglycan and NCAM immunocytochemistry
Gene_expression (immunocytochemistry) of NCAM
13) Confidence 0.30 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1790898 Disease Relevance 0 Pain Relevance 0.06
Ricci et al. used NCAM as an indicator of the extent of muscle glycoprotein sialylation; in HIBM, muscle NCAM was found to be hyposialylated [23].
Gene_expression (used) of NCAM in muscle associated with muscle disease
14) Confidence 0.30 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1790898 Disease Relevance 0.95 Pain Relevance 0
On the basis of on the intensity of CD56 staining, human NK cells have been recently subdivided into two distinct subsets with distinct functional characteristics.
Gene_expression (staining) of CD56 in NK cells
15) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.42 Pain Relevance 0.23
-), NK T cells (CD56+/TCR-??
Gene_expression (/) of CD56 in T cells
16) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064882 Disease Relevance 1.40 Pain Relevance 0.31
The fraction>1.075 gm/ml contained cells expressing nestin and PSA-NCAM.
Gene_expression (expressing) of PSA-NCAM
17) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.09 Pain Relevance 0.03
In PN-1 treated embryos, NCAM immunoreactivity was instead present at stage 19.
Gene_expression (immunoreactivity) of NCAM in stage 19
18) Confidence 0.18 Published 2002 Journal BMC Dev Biol Section Body Doc Link PMC65692 Disease Relevance 0 Pain Relevance 0
Type 2 and 3 progenitors express Tbr2, doublecortin (DCX), and polysialic acid-neural cell adhesion molecule (PSA-NCAM).
Gene_expression (express) of PSA-NCAM in neural associated with adhesions
19) Confidence 0.17 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.10 Pain Relevance 0.03
Type 2 and 3 progenitors express Tbr2, doublecortin (DCX), and polysialic acid-neural cell adhesion molecule (PSA-NCAM).
Gene_expression (express) of acid-neural cell adhesion molecule in neural associated with adhesions
20) Confidence 0.15 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0.10 Pain Relevance 0.03

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