INT133906

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.90
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ncam1) cell adhesion (Ncam1) plasma membrane (Ncam1)
Anatomy Link Frequency
sciatic nerve 2
muscle 2
olfactory bulb 2
dorsal horn 2
neural 2
Ncam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 99.78 Very High Very High Very High
Dorsal horn 3 99.68 Very High Very High Very High
Spinal cord 3 98.68 Very High Very High Very High
Sciatic nerve 5 98.24 Very High Very High Very High
fluoxetine 31 97.86 Very High Very High Very High
Peripheral nervous system 4 97.04 Very High Very High Very High
tolerance 2 95.60 Very High Very High Very High
antinociception 3 94.40 High High
antidepressant 117 88.92 High High
depression 95 88.12 High High
Disease Link Frequency Relevance Heat
Adhesions 39 100.00 Very High Very High Very High
Diabetes Mellitus 1 99.70 Very High Very High Very High
Depression 102 88.12 High High
Aging 2 85.80 High High
Targeted Disruption 30 58.24 Quite High
Sprains And Strains 6 51.44 Quite High
Anxiety Disorder 29 50.00 Quite Low
Neurodegenerative Disease 26 50.00 Quite Low
Frailty 3 48.72 Quite Low
Male Infertility 2 47.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine treatment increases the expression of the neural cell adhesion molecule in the dorsal horn of the mouse spinal cord.
Positive_regulation (increases) of Gene_expression (expression) of neural cell adhesion molecule in dorsal horn associated with dorsal horn, adhesions, spinal cord and morphine
1) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16510246 Disease Relevance 0.26 Pain Relevance 1.20
In support of this is the observation that overexpression of NCAM in mouse muscle leads to sprouting both within and away from the NMJs (Walsh et al. 2000).
Positive_regulation (overexpression) of Gene_expression (overexpression) of NCAM in muscle
2) Confidence 0.35 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.18 Pain Relevance 0
In the olfactory epithelium, there is one report that the level of NCAM expression is elevated transiently after resection of the olfactory bulb [29].
Positive_regulation (elevated) of Gene_expression (expression) of NCAM in olfactory bulb
3) Confidence 0.32 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.48 Pain Relevance 0.10
Recently, it was reported that a transient increase in the expression of NCAM occurs in neurons after transection of the sciatic nerve, suggesting that NCAM is also involved in regeneration of the peripheral nervous system [20].
Positive_regulation (increase) of Gene_expression (expression) of NCAM in sciatic nerve associated with peripheral nervous system and sciatic nerve
4) Confidence 0.32 Published 2007 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1874509 Disease Relevance 0.36 Pain Relevance 0.10
m) were prepared, deparaffinized and stained with hematoxylin and eosin (H&E), or used for PSA-NCAM immunostaining.
Positive_regulation (used) of Gene_expression (immunostaining) of PSA-NCAM
5) Confidence 0.07 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0
Fluoxetine when treated alone restored neuronal plasticity related hippocampal alterations in diabetic mice [17] and increases the expression of polysialylated form of the neural cell adhesion molecule (PSA-NCAM) and synaptophysin (through 5-HT3 receptors), which are involved in synaptic remodeling and density, respectively [311].
Positive_regulation (increases) of Gene_expression (expression) of neural cell adhesion molecule in neural associated with diabetes mellitus, adhesions and fluoxetine
6) Confidence 0.06 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.61 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox