INT133919

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.53
Pain Relevance 4.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
paw 4
NOS1 2
spinal cords 2
brain 2
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 70 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
opioid receptor 8 99.90 Very High Very High Very High
Spinal cord 50 99.78 Very High Very High Very High
Multiple sclerosis 56 99.54 Very High Very High Very High
cocaine 18 99.52 Very High Very High Very High
agonist 95 96.52 Very High Very High Very High
alcohol 75 96.00 Very High Very High Very High
Endep 2 94.92 High High
Gabapentin 2 93.88 High High
Disease Link Frequency Relevance Heat
Demyelinating Disease 52 99.54 Very High Very High Very High
Nervous System Injury 4 99.48 Very High Very High Very High
Stress 96 99.32 Very High Very High Very High
Targeted Disruption 27 99.04 Very High Very High Very High
Neuropathic Pain 22 92.28 High High
Hyperalgesia 5 90.52 High High
Motor Neuron Diseases 44 88.64 High High
Injury 8 85.12 High High
Depression 111 56.96 Quite High
Drug Dependence 42 54.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic treatment with heroin increased (p>0.05) while cocaine significantly (p<0.05) increased CB2 gene expression in mouse brain preparations using RT-PCR (Fig. 1C).
Positive_regulation (increased) of Gene_expression (expression) of CB2 gene in brain associated with cocaine
1) Confidence 0.70 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.32 Pain Relevance 0.66
Effects of CB2-R activation and blockade on anhedonia induced by chronic mild stress (CMS)
Positive_regulation (induced) of Gene_expression (activation) of CB2-R associated with stress
2) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.80 Pain Relevance 0.31
These behavioral changes were accompanied after surgery by an increase of c-Fos expression and by an overexpression of mu-opioid and cannabinoid CB1 and CB2 receptors in the spinal cord and the dorsal hind paw skin.
Positive_regulation (increase) of Gene_expression (overexpression) of CB2 in paw associated with cannabinoid, opioid and spinal cord
3) Confidence 0.49 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16511871 Disease Relevance 0.96 Pain Relevance 1.30
These behavioral changes were accompanied after surgery by an increase of c-Fos expression and by an overexpression of mu-opioid and cannabinoid CB1 and CB2 receptors in the spinal cord and the dorsal hind paw skin.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CB2 in paw associated with cannabinoid, opioid and spinal cord
4) Confidence 0.49 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16511871 Disease Relevance 0.95 Pain Relevance 1.28
Floating sections were incubated with 1% hydrogen peroxide in phosphate-buffered saline (PBS) for 10 min at room temperature to inhibit endogenous peroxidase, washed three times with PBS, incubated for 1 h in 3% normal goat serum (NGS) in Tris-buffered saline (TBS), pH 7.4 at 22°C, incubated in primary CB2 antibody obtained from (Santa Cruz, Ca, USA), diluted 1: 300 in TBS containing 3% NGS for 24 h at 4°C, rinsed, incubated for 1 h at 22°C in 1?
Positive_regulation (incubated) of Gene_expression (antibody) of CB2
5) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0 Pain Relevance 0
N9 cells were transfected with specific murine CB2 targeting siRNA designed to knockdown murine CB2 expression (Humesis Biotechnology Corporation, New Orleans, LA).
Positive_regulation (transfected) of Gene_expression (transfected) of CB2
6) Confidence 0.40 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0 Pain Relevance 0
Moreover, although the basal levels of DOPr and CB2R mRNA were similar between WT and NOS-KO animals, nerve injury only decreased (DOPr) or increased (CB2R) their expression in the dorsal root ganglia of WT and NOS2-KO mice, and not in NOS1-KO mice.
Positive_regulation (increased) of Gene_expression (expression) of CB2R in NOS1 associated with targeted disruption, nervous system injury and opioid receptor
7) Confidence 0.36 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20498253 Disease Relevance 0.88 Pain Relevance 0.95
The studies reported here demonstrate that MS spinal cord contained increased levels of COX-2, CB2 and P2X7 receptor in affected regions compared to control spinal cords.
Positive_regulation (increased) of Gene_expression (levels) of CB2 in spinal cords associated with multiple sclerosis and spinal cord
8) Confidence 0.17 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 0.62 Pain Relevance 0.37

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