INT133943

Context Info Confidence 0.00 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.73

plasma membrane (DNM2, OPRL1) enzyme binding (DNM2) GTPase activity (DNM2) signal transducer activity (OPRL1) cytoplasm (DNM2) cytosol (DNM2)

DNM2 (Homo sapiens) OPRL1 (Homo sapiens)

Pain Link Frequency Relevance Heat Kappa opioid receptor 8 100.00 Dynorphin 4 100.00 opioid receptor 2 100.00 Endogenous opioid 1 96.80 Potency 3 71.60 Nucleus accumbens 1 36.00 Hippocampus 1 33.12 Pain 3 25.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we characterized interactions of big dynorphin (Big Dyn), a 32-amino acid prodynorphin-derived peptide consisting of Dyn A and Dyn B, with human KOR, mu- (hMOR) and delta- (hDOR) opioid receptors and opioid receptor-like receptor 1 (hORL1) expressed in cells transfected with respective cDNA.

Dyn Binding (interactions) of hORL1 associated with dynorphin, kappa opioid receptor and opioid receptor

1) Confidence 0.00 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.73

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