INT133953

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 3.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (ARFGEF1) nucleolus (ARFGEF1) nucleus (ARFGEF1)
intracellular (ARFGEF1) cytoplasm (ARFGEF1)
Anatomy Link Frequency
caudate nucleus 1
nucleus accumbens 1
cerebrospinal fluid 1
hippocampus 1
ARFGEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nucleus accumbens 5 97.16 Very High Very High Very High
Hippocampus 5 95.72 Very High Very High Very High
Kappa opioid receptor 40 94.32 High High
opioid receptor 10 91.80 High High
Potency 15 90.60 High High
Dynorphin 20 85.04 High High
Endogenous opioid 5 80.68 Quite High
Pain 15 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dyn A was more selective for hKOR over hMOR, hDOR and hORL1 than Big Dyn, while Dyn B demonstrated low selectivity.
Gene_expression (selective) of Big
1) Confidence 0.07 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.76
Immunoreactive Big Dyn was detected using the combination of radioimmunoassay (RIA) and HPLC in the human nucleus accumbens, caudate nucleus, hippocampus and cerebrospinal fluid (CSF) with the ratio of Big Dyn and Dyn B being approximately 1:3.
Gene_expression (detected) of Big in cerebrospinal fluid associated with nucleus accumbens and hippocampus
2) Confidence 0.07 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.78
Immunoreactive Big Dyn was detected using the combination of radioimmunoassay (RIA) and HPLC in the human nucleus accumbens, caudate nucleus, hippocampus and cerebrospinal fluid (CSF) with the ratio of Big Dyn and Dyn B being approximately 1:3.
Gene_expression (detected) of Big in nucleus accumbens associated with nucleus accumbens and hippocampus
3) Confidence 0.02 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.78
Immunoreactive Big Dyn was detected using the combination of radioimmunoassay (RIA) and HPLC in the human nucleus accumbens, caudate nucleus, hippocampus and cerebrospinal fluid (CSF) with the ratio of Big Dyn and Dyn B being approximately 1:3.
Gene_expression (detected) of Big in hippocampus associated with nucleus accumbens and hippocampus
4) Confidence 0.02 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.78
Immunoreactive Big Dyn was detected using the combination of radioimmunoassay (RIA) and HPLC in the human nucleus accumbens, caudate nucleus, hippocampus and cerebrospinal fluid (CSF) with the ratio of Big Dyn and Dyn B being approximately 1:3.
Gene_expression (detected) of Big in caudate nucleus associated with nucleus accumbens and hippocampus
5) Confidence 0.02 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515546 Disease Relevance 0 Pain Relevance 0.78

General Comments

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