INT133958

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Context Info
Confidence 0.79
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.65
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) plasma membrane (Bdkrb2) signal transducer activity (Bdkrb2)
Anatomy Link Frequency
plasma 1
Bdkrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
b2 receptor 2 100.00 Very High Very High Very High
bradykinin 17 95.08 Very High Very High Very High
nociceptor 5 92.24 High High
Pain 3 90.76 High High
Inflammation 2 86.88 High High
Neuropeptide 2 85.00 Quite High
Root ganglion neuron 2 75.64 Quite High
Acute pain 1 56.72 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 3 96.64 Very High Very High Very High
Pain 2 90.76 High High
INFLAMMATION 2 86.88 High High
Ganglion Cysts 2 75.32 Quite High
Injury 1 55.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Potentially, the colocalization of EP24.15/16 and B2R at plasma membrane microdomains known as lipid rafts in a physiologically relevant nociceptive system would allow for discrete, peptidase regulation of BK signaling.
Localization (colocalization) of B2R in plasma associated with nociception and bradykinin
1) Confidence 0.79 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.27 Pain Relevance 0.60
This depended on the B2 receptor, PLC activation, and inositol triphosphate-mediated Ca2+ release.
Localization (release) of B2 receptor associated with b2 receptor
2) Confidence 0.26 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485565 Disease Relevance 0.38 Pain Relevance 0.68

General Comments

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