INT133972

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 0.53
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Meis1) DNA binding (Meis1)
Anatomy Link Frequency
Pit 2
endometrium 1
Meis1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 2 80.72 Quite High
Pain 2 79.96 Quite High
Central nervous system 2 79.32 Quite High
Neuropeptide 4 75.32 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
endometriosis 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 97.72 Very High Very High Very High
Leukemia 20 83.60 Quite High
Pain 2 79.96 Quite High
Myeloid Leukemia 4 73.52 Quite High
Acute Myeloid Leukemia 16 66.08 Quite High
Cancer 12 55.52 Quite High
Hyperplasia 4 49.44 Quite Low
Neuroblastoma 8 39.20 Quite Low
Hypersensitivity 12 23.00 Low Low
Anaemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This antibody was raised against a C-terminal epitope of human MEIS1, and recognizes both human MEIS1 and murine Meis1, since their protein sequences are identical in that region (also see below, section MEIS1 constructs).
Meis1 Binding (recognizes) of
1) Confidence 0.48 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
This antibody was raised against a C-terminal epitope of human MEIS1, and recognizes both human MEIS1 and murine Meis1, since their protein sequences are identical in that region (also see below, section MEIS1 constructs).
MEIS1 Binding (recognizes) of
2) Confidence 0.48 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
MEIS1 physically interacts with 5?
MEIS1 Binding (interacts) of
3) Confidence 0.48 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.10 Pain Relevance 0
It is likely that a similar regulation occurs with HOXA10 and MEIS1 cofactor in the endometrium.
MEIS1 Spec (likely) Binding (occurs) of in endometrium
4) Confidence 0.37 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.28 Pain Relevance 0
Electromobility shift assays revealed one region that may interact with the homeobox proteins Oct-1, PDX1, Pit-1 and MEIS and two consensus DRE sites that bind a nuclear protein, which was identified as the downstream regulatory element antagonistic modulator DREAM by supershift assays.
MEIS Binding (interact) of in Pit
5) Confidence 0.08 Published 2006 Journal Peptides Section Abstract Doc Link 16515822 Disease Relevance 0.08 Pain Relevance 0.28
Electromobility shift assays revealed one region that may interact with the homeobox proteins Oct-1, PDX1, Pit-1 and MEIS and two consensus DRE sites that bind a nuclear protein, which was identified as the downstream regulatory element antagonistic modulator DREAM by supershift assays.
MEIS Binding (bind) of in Pit
6) Confidence 0.08 Published 2006 Journal Peptides Section Abstract Doc Link 16515822 Disease Relevance 0.08 Pain Relevance 0.27

General Comments

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