INT13400

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Context Info
Confidence 0.50
First Reported 1981
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 34
Disease Relevance 4.23
Pain Relevance 15.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Enpep) peptidase activity (Enpep) plasma membrane (Enpep)
Anatomy Link Frequency
lymphocytes 1
brain 1
kidney 1
Enpep (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 27 100.00 Very High Very High Very High
Desipramine 4 99.88 Very High Very High Very High
Antinociceptive 31 99.46 Very High Very High Very High
Dynorphin 41 99.32 Very High Very High Very High
Pain threshold 2 98.88 Very High Very High Very High
noradrenaline 2 98.88 Very High Very High Very High
Enkephalin 53 98.76 Very High Very High Very High
agonist 15 98.60 Very High Very High Very High
intrathecal 5 98.40 Very High Very High Very High
Analgesic 22 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pre-eclampsia 230 99.64 Very High Very High Very High
Pain 11 98.88 Very High Very High Very High
Ataxia 1 93.72 High High
Anxiety Disorder 5 90.60 High High
Dwarfism 1 89.40 High High
Hypertension 139 88.48 High High
Proteinuria 20 84.56 Quite High
Pressure Volume 2 Under Development 15 84.40 Quite High
Cancer 8 83.92 Quite High
Pre-term Labor 135 77.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional arrest of the Psa gene and a drastic decrease of aminopeptidase activity indicated that the function of Psa is disrupted in homozygous mice.
Negative_regulation (decrease) of aminopeptidase
1) Confidence 0.50 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10407043 Disease Relevance 0.33 Pain Relevance 0.28
Both isomers were efficient as enkephalinase blockers, but only the RS isomer, designated kelatorphan, was able to strongly inhibit aminopeptidase and dipeptidylaminopeptidase.
Negative_regulation (inhibit) of aminopeptidase
2) Confidence 0.43 Published 1985 Journal J. Med. Chem. Section Abstract Doc Link 3897541 Disease Relevance 0 Pain Relevance 0.59
Intracerebroventricular injection in mice of these mixed inhibitors, especially kelatorphan, led to naloxone reversible analgesic responses (hot-plate test) that were slightly better than those produced by a mixture of thiorphan and bestatin, two potent inhibitors of enkephalinase and aminopeptidase, respectively.
Negative_regulation (inhibitors) of aminopeptidase associated with analgesic, narcan and intracerebroventricular
3) Confidence 0.37 Published 1985 Journal J. Med. Chem. Section Abstract Doc Link 3897541 Disease Relevance 0 Pain Relevance 0.66
Bestatin, an aminopeptidase inhibitor, markedly potentiated the antinociceptive response induced by dynorphin-B but not the motor dysfunction.
Negative_regulation (inhibitor) of aminopeptidase associated with dynorphin and antinociceptive
4) Confidence 0.34 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2568600 Disease Relevance 0.09 Pain Relevance 0.64
Thiorphan, an 'enkephalinase' inhibitor, and bestatin, an aminopeptidase inhibitor, decreased the turnover of noradrenaline and increased that of dopamine and serotonin in mouse brain regions.
Negative_regulation (inhibitor) of aminopeptidase in brain associated with dopamine, noradrenaline and serotonin
5) Confidence 0.34 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6594244 Disease Relevance 0 Pain Relevance 0.50
Bestatin, an aminopeptidase inhibitor with a multi-pharmacological function.
Negative_regulation (inhibitor) of aminopeptidase
6) Confidence 0.34 Published 1991 Journal Biomed. Pharmacother. Section Title Doc Link 1912369 Disease Relevance 0.22 Pain Relevance 0.12
It exerts a direct stimulating effect on lymphocytes (and monocytes) via its fixation on cell surface leucine-aminopeptidase, and an indirect effect on monocytes (and lymphocytes) via aminopeptidase B inhibition of tuftsin catabolism.
Negative_regulation (inhibition) of aminopeptidase in lymphocytes
7) Confidence 0.34 Published 1991 Journal Biomed. Pharmacother. Section Abstract Doc Link 1912369 Disease Relevance 0.24 Pain Relevance 0.11
Bestatin, the dipeptide N-((2S, 3R)-3-amino-2-hydroxy-4-phenyl butanyl) L-leucine is a leucine aminopeptidase and aminopeptidase-B inhibitor.
Negative_regulation (inhibitor) of aminopeptidase
8) Confidence 0.34 Published 1991 Journal Biomed. Pharmacother. Section Abstract Doc Link 1912369 Disease Relevance 0.19 Pain Relevance 0
Bestatin, the dipeptide N-((2S, 3R)-3-amino-2-hydroxy-4-phenyl butanyl) L-leucine is a leucine aminopeptidase and aminopeptidase-B inhibitor.
Negative_regulation (inhibitor) of aminopeptidase
9) Confidence 0.34 Published 1991 Journal Biomed. Pharmacother. Section Abstract Doc Link 1912369 Disease Relevance 0.19 Pain Relevance 0
However, amastatin, an aminopeptidase inhibitor, phosphoramidon, an endopeptidase 24.11 inhibitor, and captopril, an angiotensin-converting enzyme inhibitor, caused no changes.
Negative_regulation (inhibitor) of aminopeptidase
10) Confidence 0.29 Published 2010 Journal Neuropeptides Section Abstract Doc Link 20189644 Disease Relevance 0 Pain Relevance 1.04
Compounds (26) and (16) represent the first combined inhibitors of enkephalinase and aminopeptidase MII.
Negative_regulation (inhibitors) of aminopeptidase MII
11) Confidence 0.27 Published 1991 Journal J. Enzym. Inhib. Section Abstract Doc Link 1669442 Disease Relevance 0 Pain Relevance 0.34
However, the nociceptin effect was potentiated by combined injection of phosphoramidon and bestatin, indicating that inhibition of aminopeptidase may also contribute to inducing the behavioral response to nociceptin.
Negative_regulation (inhibition) of aminopeptidase associated with orphanin
12) Confidence 0.25 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12234609 Disease Relevance 0 Pain Relevance 0.74
As the severity of preeclampsia progresses, both APA and P-LAP enzyme activity decrease, ultimately becoming lower than that measured during normal pregnancy [42, 44].
Negative_regulation (decrease) of APA associated with pre-eclampsia
13) Confidence 0.20 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.63 Pain Relevance 0.11
Phenylmethanesulfonyl fluoride (PMSF), a serine protease inhibitor, bestatin, a general aminopeptidase inhibitor, and captopril, an angiotensin-converting enzyme inhibitor, were all inactive.
Negative_regulation (inhibitor) of aminopeptidase
14) Confidence 0.20 Published 2001 Journal Brain Res. Section Abstract Doc Link 11164832 Disease Relevance 0.07 Pain Relevance 0.70
Administration of enkephalinase inhibitors rapidly elicited marked decrease in Tyr-Gly-Gly immunoreactivity whereas bestatin, an aminopeptidase inhibitor, elicited 100% increase and captopril, an ACE inhibitor, was without significant effect.
Negative_regulation (inhibitor) of aminopeptidase
15) Confidence 0.19 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3912194 Disease Relevance 0 Pain Relevance 0.53
The antinociceptive effects of Thiorphan, an 'enkephalinase' inhibitor, or bestatin, an aminopeptidase inhibitor, as well as of their association and the pronociceptive effects of naloxone, an opiate receptor antagonist, were evaluated in various analgesic tests in mice.
Negative_regulation (inhibitor) of aminopeptidase associated with analgesic, antagonist, narcan, opiate and antinociceptive
16) Confidence 0.19 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3519246 Disease Relevance 0.07 Pain Relevance 0.70
To test the effect of various metal ions and protease inhibitors on aminopeptidase activity, the purified protein (10 µg) was pre-incubated with various concentrations of metal ions or inhibitors at 37°C for 5 minutes.
Negative_regulation (inhibitors) of aminopeptidase
17) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919393 Disease Relevance 0 Pain Relevance 0
Bestatin is a low-molecular-weight peptide that inhibits APA and APN.
Negative_regulation (inhibits) of APA
18) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.96 Pain Relevance 0.04
They also showed that treatment with an ACE inhibitor reduced kidney APA activity in SHRs, suggesting that APA expression may be positively coupled with AngII levels.
Negative_regulation (reduced) of APA in kidney
19) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0 Pain Relevance 0.04
Thus, in a comparison of a bolus injection of APA (MW 109?
Negative_regulation (injection) of APA
20) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.57 Pain Relevance 0

General Comments

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