INT134008

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 6.12
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 1
spinal cord 1
pituitary 1
brainstem 1
PVN 1
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 18 99.68 Very High Very High Very High
substance P 4 99.68 Very High Very High Very High
depression 28 99.52 Very High Very High Very High
Enkephalin 7 99.00 Very High Very High Very High
Spinal cord 16 98.30 Very High Very High Very High
amygdala 56 98.00 Very High Very High Very High
medulla 24 97.60 Very High Very High Very High
Visceral pain 6 96.88 Very High Very High Very High
Neuropeptide 58 95.72 Very High Very High Very High
Eae 22 93.84 High High
Disease Link Frequency Relevance Heat
Cystitis 6 99.84 Very High Very High Very High
Stress 206 99.68 Very High Very High Very High
Depression 28 99.52 Very High Very High Very High
Body Weight 8 98.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 96.88 Very High Very High Very High
Urological Neuroanatomy 2 95.20 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 95.12 Very High Very High Very High
Pain 8 91.48 High High
Targeted Disruption 132 90.08 High High
Anxiety Disorder 60 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, CRH heteronuclear (hn) RNA and mRNA expression are significantly decreased in adrenalectomized rats, after stress stimulation (Tanimura and Watts, 1998).
Transcription (expression) of CRH associated with stress
1) Confidence 0.59 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.25 Pain Relevance 0
It is probably undeniable that the cAMP/PKA pathway activates the vasopressin and CRH gene transcription, because of the large amount of evidence attesting to it; however, the whole picture about other regulators has not yet been fully elucidated.
Transcription (transcription) of CRH gene
2) Confidence 0.59 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.04
We tested the hypothesis that in the spinal cord CRF and Ucn1 control peripheral components of the stress response, by assessing the distribution of CRF- and Ucn1-containing fibers, CRF1 and CRF2 mRNAs, and CRF receptor protein (CRFR) in the mouse spinal cord, by using immunofluorescence and in situ hybridization.
Transcription (distribution) of CRF in spinal cord associated with stress and spinal cord
3) Confidence 0.58 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17444496 Disease Relevance 0.19 Pain Relevance 0.21
The mRNA of CRH-BP is detected in the cerebral cortex, limbic systems including amygdala, brainstem, and pituitary corticotroph (Potter et al. 1992).
Transcription (detected) of CRH in pituitary associated with medulla, amygdala and cerebral cortex
4) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.07 Pain Relevance 0.27
Three serial GRE half-sites are recognized in the above short sequences, all of which are involved in the negative regulation of the CRH gene transcription by the direct binding of GR. 8-bromo cAMP-induced CRH gene promoter activity is significantly reduced by glucocorticoid in AtT20 cells; however, this suppressive effect is abolished in the deleted or mutated construct lacking these nGRE site(s).
Transcription (transcription) of CRH gene in AtT20
5) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.10
In the present study, we examined the effects of CP-induced cystitis on the levels of mRNAs encoding galanin, corticotropin-releasing hormone (CRH), substance P, and enkephalins in the hypothalamic and limbic nuclei using in situ hybridization histochemistry in mouse.
Transcription (levels) of corticotropin-releasing hormone associated with cystitis, enkephalin and substance p
6) Confidence 0.53 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335920 Disease Relevance 0.48 Pain Relevance 0.62
CRH mRNA levels in CP-treated group also increased significantly in the central amygdala as well as the PVN after the CP administration.
Transcription (levels) of CRH mRNA in PVN associated with amygdala
7) Confidence 0.53 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335920 Disease Relevance 0.50 Pain Relevance 0.66
Levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary were significantly increased, and glucocorticoid receptor protein expression in the hypothalamus paraventricular nucleus was downregulated in the depression-like model mice.
Transcription (expression) of corticotropin-releasing hormone mRNA in hypothalamus associated with depression
8) Confidence 0.51 Published 2006 Journal Phytomedicine Section Abstract Doc Link 16516452 Disease Relevance 1.10 Pain Relevance 0.51
Stress induces ICER expression in different parts of the HPA axis, and ICER regulates transcription of the CRH gene during stress [24, 25, 45].
Transcription (transcription) of CRH gene associated with stress
9) Confidence 0.26 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.98 Pain Relevance 0.27
Thus, ICER activation, by suppressing CRH transcription, serves as a protective mechanism helping to avoid the consequences of excessive expression of CRH [24, 25, 45].
Transcription (transcription) of CRH
10) Confidence 0.26 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.98 Pain Relevance 0.39
Under normal conditions, stimulation of the cAMP cascade by stress produces a dual effect: first facilitating CRH gene transcription via phospho-CREB, and later inhibiting it via induction of ICER.
Transcription (transcription) of CRH gene associated with stress
11) Confidence 0.26 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2699388 Disease Relevance 0.96 Pain Relevance 0.32
The mRNA of CRH-BP is detected in the cerebral cortex, limbic systems including amygdala, brainstem, and pituitary corticotroph (Potter et al. 1992).
Transcription (detected) of CRH in amygdala associated with medulla, amygdala and cerebral cortex
12) Confidence 0.19 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.07 Pain Relevance 0.27
The mRNA of CRH-BP is detected in the cerebral cortex, limbic systems including amygdala, brainstem, and pituitary corticotroph (Potter et al. 1992).
Transcription (detected) of CRH in brainstem associated with medulla, amygdala and cerebral cortex
13) Confidence 0.19 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.07 Pain Relevance 0.27

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