INT134019

Context Info Confidence 0.12 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.66

Anatomy Link Frequency neurons 2 Kcnk2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Dopamine 3 100.00 cocaine 2 99.80 opioid receptor 9 98.40 Opioid 1 95.84 addiction 1 93.72 Neurotransmitter 1 92.00 Delta opioid receptors 1 75.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In support of this, cocaine-mediated increases in activation of dopamine D1 receptors (D1R) results in a desensitization of delta-opioid receptor (DOR) signaling through adenylyl cyclase (AC) in striatal neurons.

Positive_regulation (increases) of Positive_regulation (activation) of D1R in neurons associated with dopamine, opioid receptor and cocaine

1) Confidence 0.12 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16517070 Disease Relevance 0 Pain Relevance 0.66

General Comments

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