INT134036

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.42
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b)
cytoplasm (Gsk3b) cytosol (Gsk3b) nucleolus (Gsk3b)
Anatomy Link Frequency
cortex 1
Gsk3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 8 98.80 Very High Very High Very High
sSRI 3 98.50 Very High Very High Very High
fluoxetine 2 93.28 High High
Mechanotransduction 1 84.00 Quite High
Morphine 4 83.80 Quite High
depression 1 77.92 Quite High
Opioid 4 75.00 Quite High
ischemia 4 73.88 Quite High
GABAergic 3 72.56 Quite High
MU agonist 1 49.88 Quite Low
Disease Link Frequency Relevance Heat
Osteoporosis 11 99.64 Very High Very High Very High
Major Depressive Disorder 8 97.80 Very High Very High Very High
Depression 1 77.92 Quite High
Manic Depressive Disorder 1 77.04 Quite High
Schizophrenia 1 76.32 Quite High
Autism 1 75.72 Quite High
Urological Neuroanatomy 1 75.00 Quite High
Cv Unclassified Under Development 4 73.88 Quite High
Osteogenic Sarcomas 1 67.24 Quite High
Body Weight 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings show, for the first time, that GSK3B genetic variants play a role in the SSRI antidepressant therapeutic response and support the hypothesis that drugs regulating GSK3B activity may represent a novel treatment strategy for MDD.
Regulation (regulating) of GSK3B associated with antidepressant, major depressive disorder and ssri
1) Confidence 0.60 Published 2008 Journal Pharmacogenomics J. Section Abstract Doc Link 18195729 Disease Relevance 0.43 Pain Relevance 0.46
These data suggest that OIC occurs via the JAK2 regulation of PI3K pathway-dependent STAT3, Akt, and GSK-3 beta, with GSK-3 beta contributing a central role in acute OIC.
Regulation (regulation) of GSK-3 beta
2) Confidence 0.34 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.13 Pain Relevance 0.41
The current study investigated whether chronic administration of psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid) used in the treatment of psychiatric disorders alters levels of Reelin, its receptor Vldlr, downstream molecules Gsk3 beta, Dab-1, and Gad65/67 in rat prefrontal cortex as measured by qRT-PCR and SDS-PAGE and western blotting. qRT-PCR revealed that mRNAs for Reelin, Vldlr, Dab-1, Gsk3 beta, and Gad65 were each significantly altered by at least one of the drugs tested, and in the case of Reelin, Dab-1, and Gsk3 beta, by multiple drugs.
Regulation (altered) of Gsk3 beta in cortex associated with fluoxetine
3) Confidence 0.11 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.38 Pain Relevance 0.23
hours affected osteoblastic maturation by up-regulating early local factors, such as transforming growth factor (TGF)-?
Regulation (regulating) of factor associated with osteoporosis
4) Confidence 0.03 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952315 Disease Relevance 0.48 Pain Relevance 0.04

General Comments

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