INT134040

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.07
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
granulocyte 1
Jak2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 22 98.48 Very High Very High Very High
Arthritis 48 90.48 High High
Morphine 4 84.00 Quite High
Inflammation 22 82.92 Quite High
Opioid 4 75.00 Quite High
spinal inflammation 1 75.00 Quite High
ischemia 3 74.08 Quite High
psoriasis 3 64.24 Quite High
MU agonist 1 50.08 Quite High
cytokine 29 36.96 Quite Low
Disease Link Frequency Relevance Heat
Hematological Disease 4 99.62 Very High Very High Very High
Rheumatoid Arthritis 22 98.48 Very High Very High Very High
Arthritis 52 90.48 High High
Inflammatory Bowel Disease 1 83.48 Quite High
Low Back Pain 1 75.00 Quite High
Cv Unclassified Under Development 3 74.08 Quite High
Psoriasis 3 64.24 Quite High
INFLAMMATION 20 50.00 Quite Low
Disease 10 21.60 Low Low
Immunization 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that OIC occurs via the JAK2 regulation of PI3K pathway-dependent STAT3, Akt, and GSK-3 beta, with GSK-3 beta contributing a central role in acute OIC.
Regulation (regulation) of JAK2
1) Confidence 0.41 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.13 Pain Relevance 0.47
There was no difference in the distribution of allele and genotype in either JAK2 or STAT3 between AS groups and controls.
Neg (no) Regulation (difference) of JAK2
2) Confidence 0.39 Published 2010 Journal Clin. Immunol. Section Abstract Doc Link 20627814 Disease Relevance 0.16 Pain Relevance 0.12
It is this established role of JAK2 in regulating granulocyte hematopoiesis that suggests the involvement of JAK2 inhibition in the PBNC reductions in RA patients.
Regulation (involvement) of JAK2 in granulocyte associated with hematological disease and rheumatoid arthritis
3) Confidence 0.36 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.78 Pain Relevance 0.34

General Comments

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