INT134041

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.71
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
hearts 2
megakaryocyte 1
Jak2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 99.74 Very High Very High Very High
agonist 41 95.68 Very High Very High Very High
cytokine 18 92.88 High High
Opioid 4 88.84 High High
ischemia 46 88.64 High High
MU agonist 1 82.92 Quite High
Inflammation 54 67.36 Quite High
dexamethasone 1 62.28 Quite High
headache 2 50.80 Quite High
antagonist 5 43.28 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 373 98.64 Very High Very High Very High
Myocardial Infarction 103 89.84 High High
Cv Unclassified Under Development 44 88.64 High High
Frailty 6 84.64 Quite High
Shock 2 82.96 Quite High
Diabetic Cardiomyopathies 210 82.20 Quite High
Apoptosis 11 79.76 Quite High
Thrombocytopenia 60 75.40 Quite High
Appetite Loss 28 72.96 Quite High
Pressure And Volume Under Development 62 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine induced the phosphorylation of JAK2, yet not JAK1, in the area at risk.
Phosphorylation (phosphorylation) of JAK2 associated with morphine
1) Confidence 0.75 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.25 Pain Relevance 0.85
Since we did not observe modifications in the phosphorylation of JAK2 and the downstream targets of mTOR after exercise, these data suggest that the cross-talk between insulin, IL-6 and leptin have an essential role in controlling food intake after exercise.
Phosphorylation (phosphorylation) of JAK2
2) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.06 Pain Relevance 0
One study examined the hypothesis that phosphorylation of Janus kinase 2 (Jak2) upstream of PI3K is impaired in diabetic hearts by an AT1 receptor-mediated mechanism.
Phosphorylation (phosphorylation) of Jak2 in hearts associated with diabetes mellitus
3) Confidence 0.53 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.14 Pain Relevance 0
One study examined the hypothesis that phosphorylation of Janus kinase 2 (Jak2) upstream of PI3K is impaired in diabetic hearts by an AT1 receptor-mediated mechanism.
Phosphorylation (phosphorylation) of Janus kinase 2 in hearts associated with diabetes mellitus
4) Confidence 0.53 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.14 Pain Relevance 0
IL-6 caused a significant reduction in food intake (Figure 2f) and induced hypothalamic JAK2 and STAT3 phosphorylation (Figures 2g and h).
Phosphorylation (phosphorylation) of JAK2
5) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.20 Pain Relevance 0
and prevent JAK2 and STAT3 phosphorylation

[32, 105].

Phosphorylation (phosphorylation) of JAK2
6) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 0.54 Pain Relevance 0.39
Binding to TPO receptor with a high affinity induces megakaryocyte differentiation via phosphorylation of JAK2 and STAT5.
Phosphorylation (phosphorylation) of JAK2 in megakaryocyte
7) Confidence 0.09 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880346 Disease Relevance 0.39 Pain Relevance 0.12

General Comments

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